刘静霞 - 华中农业大学

个人简介

教育经历 2002.9−2005.7：中国科学院水生生物研究所，遗传学博士 1999.9−2002.7：华中农业大学和中科院水生生物研究所合作培养，水产学硕士 1995.9−1999.7：华中农业大学，获农学学士学位主要职历 2013.12−至今：华中农业大学水产学院，教授 2011.3−2012.9: 美国哈佛大学医学院, 访问/博后研究 2009.7−2013.12：中国科学院水生生物研究所，副研究员 2006.2−2009.7：中国科学院水生生物研究所，助理研究员

研究领域

主要从事鱼类逆境发育遗传学研究，开展2个方面的工作：（1）环境胁迫（生物或非生物胁迫）下鱼类发育与遗传学基础研究，主要探讨环境因子与基因的调控互作网络在鱼类胚胎造血（造血干/前体细胞）发育以及鱼类行为调节(神经)系统的发育过程中的分子机理，并结合组学探索环境因子致畸效应遗传的表观调控机制；（2）维持鱼类优良性状发育与遗传的环境标准制定等应用学研究，针对环境胁迫下鱼类发育与遗传的优良性状退化等渔业问题，开发相应表观分子标记，制定相应渔业标准，并进行效果评估等。

近期论文

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MingYue Chen#, JiangPing Xu#, Yi Luo#, Ming-Xian Chang, Jing-Xia Liu*. Copper regulates the susceptibility of zebrafish larvae to inflammatory stimuli by controlling neutrophil/macrophage survival. Frontiers in Immunology, 2019, online. ZhiPeng Tai#, PengPeng Guan#, ZiYang Wang, LingYa Li, Ting Zhang, GuoLiang Li*, Jing-Xia Liu*. Common responses of fish embryos to metals: An integrated analysis of transcriptomes and methylomes in zebrafish embryos under the stress of copper ions or silver nanoparticles. Metallomics, 2019, 11(9): 1452 – 1464. (封面论文) Jing-Xia Liu*, Qin-Han Xu, Sen Li, XueDong Yu, WenYe Liu, Gang Ouyang, Ting Zhang, Ling-Ling Chen. Transcriptional factor Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-beta signaling. BBA-Gene Regulatory Mechanisms, 2017, 1860: 1103-1116. Jing-Xia Liu*, Qin-Han Xu, Ting Zhang, Xunwei Xie, Gang Ouyang. Eaf1 and Eaf2 pattern the zebrafish dorsoventral axis via distinctively and spatially suppressing β-Catenin1 and β-Catenin2 activity. International Journal of Biological Sciences，2018, 14, 705 716. Ting Zhang, Lian Xu, Jun-Jie Wu, Wei-Min Wang, Jie Mei, Xu-Fa Ma*, Jing-Xia Liu*. Transcriptional responses and mechanisms of copper-induced dysfunctional locomotor behavior in zebrafish embryos. ToxSci, 2015, 148（1）：299-310. Jing-Xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate Canonical Wnt/β-catenin Signaling. Development, 2013, 140, 1067-1078.（第一作者, 该论文被“Development”杂志点评为亮点论文） Chun-Xiao Huang#, Huang Yan#, Xue-Ke Duan, Mu Zhang, Jia-Peng Tu, Jing-Xia Liu, Hong Liu, Tian-Sheng Chen, Wei-Min Wang, Wang Huan-Ling*. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death & Differentiation, 2019, 26, 1531-1544. Cong Xu#, Mohammadsharif Tabebordbar#, Salvatore Iovino#, Christie Ciarlo, Jingxia Liu, Alessandra Castiglioni, Emily Price, Min Liu, Elisabeth R Barton, Ronald C. Kahn, Amy J. Wagers*, Leonard I. Zon*. A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species. Cell, 2013, 155(4): 909-21. （封面论文，前3位作者为共同第一作者） HaoJie Sun#, MingYue Chen#, ZiYang Wang, Guang Zhao, Jing-Xia Liu*. Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental Pollution, 2019, doi: https:// doi.org/10.1016/j.envpol.2019.113364. （IF: 5.7） Guang Zhao#, ZiYang Wang#, Lian Xu, Cheng-Xing Xia, Jing-Xia Liu*, 2019. Silver nanoparticles induce abnormal touch responses by damaging neural circuits in zebrafish embryos. Chemosphere, 229, 169-180 （IF:5.11） ZiYang Wang#, ZhangCheng Ding#, Qin-Han Xu, Jing-Xia Liu*, 2019. Mechanism responses to silver nanoparticles stresses during zebrafish embryogenesis. Chemosphere, 222, 991-1002（IF:5.11） YanJun Zhang#, ZhangCheng Ding#, Guang Zhao#, Ting Zhang, QinHan Xu, Bei Cui, Jing-Xia Liu*. Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos. Journal of Hazardous Materials, 2018, 344:1057-1068.（IF: 6.4） YanJun Zhang#, ZiYang Wang #, Guang Zhao, Jing-Xia Liu*. Silver nanoparticles affect Lens rather than retina development in zebrafish embryos. Ecotoxicology and Environmental Safety, 2018, 163:279-288 (IF:4.8)