寮渭巍 - 吉林大学

研究领域

1.不对称催化构建具有多官能团手性季碳中心的新方法开发及应用研究； 2.发展新型的烯烃双官能团化反应的研究； 3.合成、设计生物活性分子，研究其生物活性。

近期论文

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Synthesis of functionalized 1,2-dihydropyridines bearing quaternary carbon centers via an organocatalytic allylic alkylation.(PDF) Gong-Feng Zou, Zhi-Peng Hu, Shi-Qiang Zhang, Wei-Wei Liao*. Tetrahedron Lett.，10.1016/j.tetlet.2014.12.116. Diastereoselective allylic rearrangement of Morita-Baylis-Hillman C-adducts: a facile access to functionalized 1, 2-dihydroisoquinolines. (PDF) Qiu-Qin Xu, Tian-You Qin, Ting-Ting Wang, Hai-Jing Wang, Wei-Wei Liao*. Tetrahedron, 10.1016/j.tet.2014.12.073. Lewis Base-Promoted Rearrangement of Allylic Cyanohydrins: Construction of Functionalized Nitriles Bearing 1,3-Diketone Moieties. (PDF) Yan-Jing Zhang, Qi-Lan Hou, Hai-Jing Wang,* and Wei-Wei Liao*. J. Org.Chem.,2014, 79, 10890 − 10898. Lewis Base-Catalyzed Allylic Alkylation of α-Amino Nitriles and Cyanohydrins and Synthetic Applications. (Account) (PDF) Tian-You. Qin, Sean Xiao-An, Zhang and Weiwei, Liao*. Chin. J. Org. Chem., 2014, 34 (11), 2187-2194. Metal-Free Intramolecular Carbocyanation of Alkenes: Catalytic Stereoselective Construction of Pyrrolo[2,1-a]isoquinolines with Multiple Substituents. (PDF) Jian-Ming Chen, Qiu-Qin Xu, and Weiwei Liao*. Chem. Eur. J. , 2014, 20, 13876-13880. Asymmetric Synthesis of Functionalized Dihydronaphthoquinones Containing Quaternary Carbon Centers via a Metal-Free Catalytic Intramolecular Acylcyanation of Activated Alkenes. (PDF) Zhe Zhuang, Zhi-Peng Hu, and Wei-Wei Liao*. Org. Lett., 2014, 16, 3380–3383. Nucleophilic Phosphine-Catalyzed Intramolecular Michael Reactions of N-Allylic Substituted α-Amino Nitriles: Construction of Functionalized Pyrrolidine Rings via 5-endo-trig Cyclizations. (PDF) Da En, Gong-Feng Zou, Yuan Guo, and Wei-Wei Liao*. J. Org. Chem., 2014, 79, 4456–4462. Synthesis of densely functionalized α-methylene γ-butyrolactones via an organocatalytic one-pot allylic-alkylation–cyclization reaction. (PDF) Yong Yan, Da En, Zhe Zhuang, Yuan Guo*, Wei-Wei Liao*. Tetrahedron Lett., 2014, 55, 479–482. Metal-Free-Catalyzed Intramolecular Carbocyanation of Activated Alkenes:New Entry To Access Functionalized Nitriles Containing Quaternary Carbon Centers. Zhe Zhuang, Wei-Wei Liao*. Synlett, 2014 , 25, 905-910. (Synpacts) Lewis base catalyzed asymmetric substitution/Diels–Alder cascade reaction: a rapid and efficient construction of enantioenriched diverse tricyclic heterocycles. (PDF) Gong-Feng Zou, Feng Pan, Wei-Wei Liao*. Org. Biomol. Chem., 2013, 11, 7080-7083. Metal-Free Intramolecular Carbocyanation of Activated Alkenes: Functionalized Nitriles Bearing β-Quaternary Carbon Centers. (PDF) Jian-Ming Chen, Gong-Feng Zou, Wei-Wei Liao*. Angew. Chem. Int. Ed., 2013, 52, 9296-9300.This paper has been chosen as a "Hot Paper" by the Editors for its importance in a rapidly evolving field of high current interest. Asymmetric organocatalytic allylic alkylation of Reissert compounds: a facile access to chiral 1,1-disubstituted 1,2-dihydroisoquinolines. (PDF) Tian-You Qin, Wei-Wei Liao*, Yan-Jing Zhang and Sean Xiao-An Zhang*. Org. Biomol. Chem., 2013, 11, 984-990. Controllable Regioselective Construction of Both Functional α-Methylene-β- and -γ-amino Acid Derivatives Through an Organocatalyzed Tandem Allylic Alkylation and Amination. (PDF) Feng Pan, Jian-Ming Chen, Tian-You Qin, Sean Xiao-An Zhang, and Wei-Wei Liao*. Eur. J. Org. Chem, 2012, 5324-5334. Lewis Base Promoted Intramolecular Acylcyanation of α-Substituted Activated Alkenes: Construction of Ketones Bearing β-Quaternary Carbon Centers. (PDF) Zhe Zhuang, Jian-Ming Chen, Feng Pan, and Wei-Wei Liao*. Org. Lett, 2012, 14(9), 2354-2357. A Novel Multicomponent Tandem Phosphine-Catalyzed Umpolung Reaction: Facile Access to Highly Functionalized α-Aminonitriles. Jian-Ming Chen, Yin-Zhi Fang, Zhong-lin Wei, Wei-Wei Liao*. Synthesis, 2012, 44, 1849.An invited contribution to the special issue on tandem reaction Construction of highly functional α-amino nitrilesvia a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams. (PDF) Feng Pan, Jian-Ming Chen, Zhe Zhuang, Yin-Zhi Fang, Sean Xiao-An Zhang and Wei-Wei Liao*. Org. Biomol. Chem., 2012, 10, 2214-2217. Top ten most accessed articles in February Construction of Highly Functional Quaternary Carbon Stereocenters viaan Organocatalytic Tandem Cyanation–Allylic Alkylation Reaction. (PDF) Zhe Zhuang, Feng Pan, Jian-Guo Fu, Jian-Ming Chen, and Wei-Wei Liao*. Org. Lett., 2011, 13 (23), 6164-6167. Wei-Wei, Liao, Kai Li, and Yong Tang. J. Am. Chem. Soc. , 2003, 125, 13030. Wei-Wei, Liao, Xian-Ming Deng, Yong Tang. Chem. Commun., 2004, 1516. Jun-Cheng Zheng, Wei-Wei, Liao, Xiao-Xia Sun, Xiu-Li Sun, Yong Tang, Li-Xin Dai, and Jin-Geng Deng, Org. Lett., 2005, 7, 5789.