刘星吟 - 南京医科大学

个人简介

简介：刘星吟2006年获得中山大学理学博士学位，2006年至2015年10月，先后在美国Rochester大学从事肠道病原微生物与宿主相互作用的信号转导机制的研究。2010-2015在美国爱因斯坦医学院从事自闭症关联基因的表观遗传学研究。2015年10月作为高层次引进人才受聘于南京医科大学基础医学院。2016年9月被评为南医大特聘教授，2016年被评为江苏特聘医学专家，2017年被评为江苏特聘教授，目前担任南京医科大学肠道微生态创新团队的组长，主要致力于肠道微生物与人类疾病关联的临床和基础研究。

研究领域

研究方向： 1.病原微生物以及其他环境因素对宿主信号转导和表观遗传学研究 2.肠道微生物与人类疾病

近期论文

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代表性论文 1.KunChen#,XiaotingLuan,QishaLiu,JianweiWang,XinxiaChang,AntoineM.Snijders,Jian-HuaMao,JulieSecombe,ZhouDan,Jian-HuanChen,ZibinWang,XiaoDong,ChenQiu,XiaoaiChang,DongZhang,SusanE.Celnike,andXingyinLiu*#(通讯作者)（2019）DrosophilaKDM5regulatessocialbehaviorthroughimmunecontrolandgutmicrobiotamaintenance.Cell&HostMicrobe（IF：17.8）,inpress. 2.QishaLiu,FanLi,JianXu,YaoyaoZhuang,JianweiWang,XuhuaMao,YeweiZhang,XingyinLiu*(通讯作者),(2019)AlterationingutmicrobiotaassociatedwithhepatitisBandnon-hepatitisvirusrelatedhepatocellularcarcinoma，Gutpathogen,11:1.doi:10.1186/s13099-018-0281-6. 3.JianweiWang,Yong-GuoZhang,RongLu，，ZhouDan，XinhuiFu,XinxiaChang,IkukoKato,，XingyinLiu*andJunSun*,NovelregulatoryrolesofWnt1ininfectious-associatedcoloncancer,Neoplasia,2018，20(5):499-509(通讯作者) 4.XingyinLiu*andJunSun.EntericbacterialregulationoftheWnt/β-cateninsignaling,SpringerNature,2018.MechanismsUnderlyingHost-MicrobiomeInteractionsinPathophysiologyofHumanDiseases.pp79-88(通讯作者兼第一作者) 5.XingyinLiu,JulieSecombehistonedemethylaseKDM5activatesgeneexpressionbyrecognizingchromatincontextthroughitsPHDreadermotif.CellReports,2015,13:2219-31(IF8.328) 6.XingyinLiu,ChristinaGreer,JulieSecombe.KDM5interactswithFoxotomodulate/affectcellularlevelsofoxidativestressPLoSGenetics,204,10:1371(IF6.1) 7.XngyinLiu,RongLu,ShaopingWu,Yinglinxia,Yong-guoZhangR.BalfourSartorndJunSun.Wnt2inhibitsentericbacterial-inducedinflammationinintestinalepithelialcells.InflammatoryBowelDisease,2012,18:418-429. 8.XingyinLiu,ShaopingWu,YinglinXia,XiEmmaLi,JunSun.WinglesshomologWnt11suppressesbacterialinvasionandinflammationinintestinalepithelialcells.AmericanJournalofPhysiology-GastrointestinalandLiverPhysiology,2011,301:G992-G1003. 9.XingyinLiu,RongLu,ShaopingWu,JunSun.GlobalanalysisoftheeukaryoticpathwaysandnetworksregulatedbySalmonellatyphimuriuminmouseintestinalinfectioninvivo.BMCGenomics,2010,11:722-748.(Highlyaccessed,） 10.XingyinLiu,RongLu,ShaopingWuandJunSun.SalmonellaregulationofintestinalstemcellsthroughtheWnt/beta-cateninpathway,FEBSLetters.2010,584:911-916.(Coverpaper) 11.XingyinLiu,RongLu,YinglinxiaWuandJunSun.EukaryoticsignalingpathwaystargetedbySalmonellaeffectorproteinAvrAinintestinalinfectioninvivo.BMCMicrobiology.2010,10:326-344(Highlyaccessed)。 12.Hui-chanHe,Zhao-dongHan,Qi-shanDai,Xiao-huiLing,XinFu,Zhuo-yuanLin,Ye-hanDeng,Guo-qiangQin,ChaoCai,Jia-hongChen,Fu-nengJiang,XingyinLiu*,Wei-deZhong*GlobalanalysisofthedifferentiallyexpressedmiRNAsofprostatecancerinChinesepatients.BMCGenomics,2013,14:757.(通讯作者) 13.RongLu,XingyinLiu,ShaopingWu,YinglinXia,Yong-guoZhang,ElaineOPetrof,ErikaCClaud,JunSun.Consistentactivationofthebeta-cateninpathwaybythebacterialtype-three-secretioneffectorproteinAvrAinchronicinfectedmice,AmericanJournalofPhysiology-GastrointestinalandLiverPhysiology.2012,303:G1113. 14.ShaopingWu,YinglinXia,XingyinLiu,JunSun.VitaminDreceptordeletionleadstoreductionofthetotalIkappaBalphaprotein.InternationalJournalofBiochemistry&CellBiology,2010,42:329-336. 15.ShaopingWu,ZhongdeYe,XingyinLiu,YunZhao,YinglinXia,AndrewSteiner,ElaineO.Petrof,ErikaC.Claud,JunSun.Salmonellatyphimuriuminfectionincreasesintestinalp53acetylationinintestinalepithelialcells.AmericanJournalofPhysiology-GastrointestinalandLiverPhysiology,2010,298:G784-G794. 16.RongLu,ShaopingWuXingyinLiu,YinglinXia,JunSun.ChroniceffectsofaSalmonellatype-three-secretioneffectorproteinAvrAinvivo.PLOSONE,2010,5:e10505. 17.XingYinLiu,Kam-LenDanielLee,Yong-ZhenMao,Li-PeiJin.Isolation,characterizationandphylogeneticanalysisofthecytochromebgene(cyb)fromthehypotrichousciliatePseudourostylacristata,ActaProtozool,2006,45:241–248. 18.XingYinLiu,Kam-LenDanielLee,Yong-ZhenMao,TaoLiuandLi-PeiJin(2005)Differentialgeneexpressionduringstationaryphasebetweenamicronucleatesandmicronucleatesoftheciliatedprotist,Pseudourostylacristata.Currentgenetics,2005,48:401-411.