曹新 - 南京医科大学

个人简介

曹新，博士。生物技术系主任。2001年7月毕业于上海交通大学医学院、上海医学遗传研究所遗传学专业，获博士学位。同年进入南京医学大学基础医学院任教。主要从事分子遗传学研究，重点研究人类遗传性疾病分子病因学及其临床应用，利用现代分子生物学和遗传学技术寻找新的致病基因并揭示其发病机制；通过从临床遗传学到基础分子生物学的研究，为遗传病的基因诊断、分子干预和遗传咨询提供理论基础和临床指导。近五年来在国内外专业学术期刊上共发表研究论文30多篇，SCI收录期刊论文20余篇；获国家发明专利1项、申请国家发明专利2项；先后主持国家自然科学基金面上项目2项、江苏省重点研发计划（社会发展）项目1项、江苏省自然科学基金项目2项和其他类项目5项。兼任江苏省生物化学与分子生物学学会常务理事，江苏省细胞与发育生物学学会理事。

研究领域

研究方向：遗传病分子发病机制的研究

近期论文

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发表论文（*通讯作者） 1.ChunyuLiu,JunYao,QinjunWei,GuangqianXing*,XinCao*.SpatialandtemporalexpressionpatternsofOsbpl2aandOsbpl2bduringzebrafishembryonicdevelopment.InternationalJournalofPediatricOtorhinolaryngology,2016,84:174-9. 2.ShuyaZhang,JiehuaMa,ZiyiFu,ZhileiZhang,JianCao,LeiHuang,WenquLi,PengfeiXu*,XinCao*.PromotionofbreastcancercellsMDA-MB-231invasionbydi(2-ethylhexyl)phthalatethroughmatrixmetalloproteinase-2/-9overexpression.EnvironSciPollutRes,2016,23(10):9742-9. 3.GuangqianXing,JunYao,BinWu,TingtingLiu,QinjunWei,ChengLiu,YajieLu,ZhibinChen,HengZheng,XiaonanYang,XinCao*.IdentificationofOSBPL2asanovelcausativegeneofprogressivenonsyndromichearinglossbyexomesequencing.GeneticsinMedicine,2015,17(3):210-8. 4.Li-YangMN,ShenXF,WeiQJ,YaoJ,LuYJ,CaoX,XingGQ*.IVS8+1DelG,aNovelSpliceSiteMutationCausingDFNA5DeafnessinaChineseFamily.ChinMedJ(Engl).,2015;128(18):2510-5. 5.YaoJ,QianX,BaoJ,WeiQ,LuY,ZhengH,XingG*,CaoX*.Probingtheeffectoftwoheterozygousmutationsincodon723ofSLC26A4ondeafnessphenotypebasedonmoleculardynamicssimulations.SciRep.,2015,5:10831. 6.QianXL,QinLY,XingG,CaoX*.PhenotypePredictionofPathogenicNonsynonymousSingleNucleotidePolymorphismsinWFS1.SciRep.,2015,5:14731. 7.LuYJ,YaoJ,WeiQ,XingG*,CaoX*.DiagnosticValueofSLC26A4MutationStatusinHereditaryHearingLossWithEVA:APRISMA-CompliantMeta-Analysis.Medicine,2015,94(50):e2248. 8.TanM,ShenX,YaoJ,WeiQ,LuY,CaoX*,XingG*.IdentificationofI411K,anovelmissenseEYA4mutationcausingautosomaldominantnon‑syndromichearingloss.IntJMolMed.,2014,34(6):1467-72. 9.WeiQ,ZhuH,QianX,ChenZ,YaoJ,LuY,CaoX*,XingG*.TargetedgenomiccaptureandmassivelyparallelsequencingtoidentifynovelvariantscausingChinesehereditaryhearingloss.JTranslMed.,2014,12(1):311. 10.LuY,YaoJ,YuJ,WeiQ,CaoX*.TheassociationbetweenabnormalmicroRNA-10bexpressionandcancerrisk:ameta-analysis.SciRep.,2014,4:7498. 11.HanXH,FanY,WeiQJ,XingGQ,CaoX*.Understandingofthemolecularevolutionofdeafness-associatedpathogenicmutationsofconnexin26.Genetica,2014,142(6):555-62. 12.QinjunWei,YouguoLiu,ShuaiWang,TingtingLiu,YajieLu,GuangqianXing*andXinCao*.AnovelcompoundheterozygousmutationintheGJB2genecausingnon-syndromichearinglossinafamily.InternationalJournalofMolecularMedicine,2014,33:310-316. 13.QinjunWei,ShuaiWang,JunYao,YajieLu,ZhibinChen,GuangqianXing*,XinCao*.GeneticmutationsofGJB2andmitochondrial12SrRNAinnonsyndromichearinglossinJiangsuProvinceofChina.JTranslationalMedicine,2013,11:163. 14.JieChen,QinjunWei,JunYao,XiaoyunQian,YanhongDai,YeYang,XinCao*,XiaGao*.IdentificationoftwoheterozygousdeafnessmutationsinSLC26A4(PDS)inaChinesefamilywithtwosiblings.InternationalJAudiology,2013,52(2):134-138. 15.QinjunWei,DanXu,ZhibinChen,HaifengLi,YajieLu,ChengLiu,XingkuanBu,GuangqianXing*,XinCao*.Maternallytransmittedaminoglycoside-inducedandnon-syndromichearinglosscausedbythe1494C>Tmutationinthemitochondrial12SrRNAgeneintwoChinesefamilies.InternationalJAudiology,2013,52(2):98-103. 16.WeiQ,HeW,YaoJ,GuoL,LuY,CaoX.IdentificationandcharacterizationofmicroRNAsexpressedinhumanbreastcancerT-47DcellsinresponsetoprolactintreatmentbySolexadeep-sequencingtechnology.BiochemBiophysResCommun.,2013,432(3):480-7. 17.JunYao,YajieLu,QinjunWei,XinCao*andGuangqianXing*.Asystematicreviewandmeta-analysisof235delCmutationofGJB2gene.JournalofTranslationalMedicine,2012,10:136 18.ChengH,ChenZ,WeiQ,LuY,XingG*,CaoX*.SinglenucleotidepolymorphismsandhaplotypesanalysisofDFNB1locusinChinesesporadichearingimpairmentpopulation.ChinMedJ.,2009,122(13):1549-53. 19.DaiD,LuY,ChenZ,WeiQ,CaoX*,XingG*.Co-segregationoftheT1095CwiththeA1555Gmutationofthemitochondrial12SrRNAgeneinapatientwithnon-syndromichearingloss.BiochemBiophylResCommun,2008,377(4):1152-1155.