个人简介

林凡，博士。近来主要的研究方向为肿瘤小分子靶向药物的个性化治疗。近年来在ClinCancerRes，IntJCancer，EurJCancer等国际癌症期刊发表论文10余篇。

研究领域

肿瘤小分子靶向药物的个性化治疗

针对关键癌症基因突变的小分子靶向药物筛选以及用基于合成致死原理的功能基因组学方法筛选新药靶点 体内，体外临床前恶性肿瘤实验模型（包括肿瘤异源移植模型以及自发肿瘤模型）的建立 肿瘤药物药动，药代（PD/PK）以及血脑屏障药物转运蛋白在限制小分子药物递送至中枢神经系统肿瘤的角色的研究 肿瘤信号通路分析

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(1)Lin,F.,etal.,Proteomicprofilingpredictsdrugresponsetonoveltargetedanticancertherapeutics.ExpertRevProteomics,[Epubaheadofprint]2016. (2)LinF,TanH.J.,GuanJ.S.,andLimY.P.Divideandconquer:subproteomicapproachestowardgastriccancerbiomarkeranddrugtargetdiscovery.ExpertRevProteomics.2014Mar31.2014，11（4）：515-530 (3)LinF,deGooijerMC,MorenoRoigE,BuilL,ChristnerSM,BeumerJH,WurdingerT,BeijnenJH,vanTellingenO.ABCB1,ABCG2andPTENdeterminetheresponseofglioblastomatotemozolomideandABT-888therapy.ClinCancerRes.2014,20(10):2703-2713 (4)IusufD,LudwigM,ElbatshA,vanEschA,vandeSteegE,WagenaarE,vanderValkM,LinF,vanTellingenO,SchinkelAH.OATP1A/1BtransportersaffectirinotecanandSN-38pharmacokineticsandcarboxylesteraseexpressioninknockoutandhumanizedtransgenicmice.MolCancerTher.2013,133(5):1222-1233 (5)LinF,BeijnenJH,vanTellingenO.TargetingonCore(Mutated)PathwaysofHigh-gradeGliomas:ChallengesofIntrinsicResistanceandDrugEffluxTransporters.CNSOncology2:3,271-288. (6)LinF,MarchettiS,PluimD,IusufD,MazzantiR,SchellensJHM,BeijnenJH,vanTellingenO.Abcc4togetherwithAbcb1andAbcg2formarobustco-operativedrugeffluxsystemthatrestrictsthebrainentryofcamptothecinanalogs.ClinCancerRes.2013Apr15;19(8):2084-95. (7)LinF,HogendijkH,BeijnenJH,vanTellingenO.SildenafilisnotausefulinhibitorofABCB1andABCG2invivo.EurJCancer.2013May;49(8):2059-64.doi:10.1016/j.ejca.2012.12.028. (8)LinF,BuilL,SherrisD,BeijnenJH,vanTellingenO.DualmTORC1andmTORC2inhibitorPalomid529penetratestheBlood-BrainBarrierwithoutrestrictionbyABCB1andABCG2.IntJCancer.2013Sep1;133(5):1222-33. (9)LinF,ChandrasekaranG,deGooijerMC,BeijnenJH,vanTellingenO.DeterminationofNVP-BEZ235,adualPI3KandmTORinhibitor,inhumanandmouseplasmaandinmousetissuehomogenatesbyreversed-phasehigh-performanceliquidchromatographywithfluorescencedetection.JChromatogrBAnalytTechnolBiomedLifeSci2012;901:9-17 (10)LinF,SherrisD,BeijnenJH,vanTellingenO.High-performanceliquidchromatographyanalysisofanovelsmall-molecule,anti-cancerdrug,Palomid529,inhumanandmouseplasmaandinmousetissuehomogenates.JChromatogrBAnalytTechnolBiomedLifeSci2011;879:3823-31. (11)LagasJS,LinF,WagenaarE,VlamingML,vanTellingenO,BeijnenJH,etal.P-glycoprotein(P-gp/Abcb1),Abcc2,andAbcc3determinethepharmacokineticsofetoposide.ClinCancerRes2010;16:130-40. (12)QuB,XuA,ZhaoYM,LinF,WeiXD,HongWS.ClinicalAnalysisof243PatientswithVitiligoandtheAssociationwithHLA-DQBI.ChinJDermatol,2003;36:693-695