胡学博 - 华中农业大学 - 植物科学技术学院

个人简介

教育背景 1997年毕业于华中农业大学，获植物保护学士学位。 1999年考入浙江大学攻读硕士学位，2004年毕业于浙江大学。工作经历 09/2012-现在，华中农业大学植物科技学院药用植物研究所教授、药用植物教研室主任。 12/2009-08/2012, 研究助理, 康乃尔大学，生物医学工程系（Research Associate, Biomedical Engineering Department, Cornell University） 11/2006-11/2009, 博士后，康乃尔大学，生物医学工程系（Postdoctoral Associate，Biomedical Engineering Department, Cornell University） 07/2004-10/2006, 助理研究员，中国科学院微生物研究所

研究领域

炎症（Inflammation）是我们研究的出发点。在现代医学与免疫学，炎症是机体抵御外来入侵物以及自身功能紊乱的一种纠错与调节机制。但是炎症反应中产生的活性氧等物质，也对正常细胞与功能有一定的副作用。大量研究表明，长期炎症可能会诱发癌症、关节炎、糖尿病、肥胖病、心血管病等一些列疾病；上述各类疾病中也伴随高水平的炎症反应。我们注意到中医有关上火的理论与西医炎症极其类似，都是描述机体的亚健康状态。因此，我们将炎症与上火对应，借助现代医学技术研究上火、去火中药。大量中药有上火或去火的功效，但是他们之间平行比较通常是模糊的。我们借助现代免疫学有关炎症的基本概念，利用炎症关系密切的几个蛋白，在分子水平定量分析中药材或者天然产物的去火能力，建立了不同药材之间定性、定量比较分析平台。利用该技术，在化学、药理学的基础上我们目前主要关注：1）天然产物抗肥胖病、糖尿病、心血管病药物的改造与评价；2）以抗炎为导向的中药辅助抗癌药物筛选；3）新一代凉茶的创制。目前已经有新型抗肥胖病与糖尿病药物前体，效果良好；中药辅助抗癌也将进入临床观察研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Mohammad Omar Faruque, Gang Feng, Md. Nurul Amin Khan, James W. Barlow, Umme Ruman Ankhi, Sheng Hu, M. Kamaruzzaman, Shaikh Bokhtear Uddin#, Xuebo Hu#. Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh. Journal of Ethonobiology and Ethnomedicine. Accepted. 2019. 2. Jafari M, Akram W, Pang Y, Ahmad A, Ahmed S, Yasin NA, Anjum T, Ali B, Hu X, Li X, Dong S, Cai Q, Ciprian M, Bielec M, Hu S, Sefidkon F, Hu X*.Genetic diversity and biogeography of T. officinale inferred from multi locus sequence typing approach.PLoS One. 2018 Sep 18;13(9):e0203275 3. Zhang Q, Hu S, Wang K, Cui M, Li X, Wang M, Hu X*. Engineering a yeast double-molecule carrier for drug screening. Artif Cells Nanomed Biotechnol. 2018 Apr 3:1-11 4. Faruque MO, Uddin SB, Barlow JW, Hu S, Dong S, Cai Q, Li X, Hu X*.Quantitative Ethnobotany of Medicinal Plants Used by Indigenous Communities in the Bandarban District of Bangladesh.Front Pharmacol. 2018 Feb 6;9:40 5. Zhan C, Ahmed S, Hu S, Dong S, Cai Q, Yang T, Wang X, Li X, Hu X*.Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida.Biochem Biophys Res Commun. 2018 Jan 1;495(1):1271-1277 6. Ahmed S, Liu H, Ahmad A, Akram W, Abdelrahman EKN, Ran F, Ou W, Dong S, Cai Q, Zhang Q, Li X, Hu S, Hu X*. Characterization of Anti-bacterial Compounds from the Seed Coat of Chinese Windmill Palm Tree (Trachycarpus fortunei).Front Microbiol. 2017 Oct 4;8:1894 7. Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X*.Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.Sci Rep. 2017 Apr 19;7:46623 8. Zhan C, Li X, Zhao Z, Yang T, Wang X, Luo B, Zhang Q, Hu Y, Hu X*. Comprehensive Analysis of the Triterpenoid Saponins Biosynthetic Pathway in Anemone flaccida by Transcriptome and Proteome Profiling. Front Plant Sci. 2016, 7:1094 9. Ahmed S, Zhan C, Yang Y, Wang X, Yang T, Zhao Z, Zhang Q, Li X, Hu X*. The Transcript Profile of a Traditional Chinese Medicine, Atractylodes lancea, Revealing Its Sesquiterpenoid Biosynthesis of the Major Active Components. PLoS One. 2016 Mar 18;11(3):e0151975 10. Xin-Mei Zhao, Zhang-Qian Wang, Shao-Hua Shu, Wen-Juan Wang, Hai-Jie Xu, Young-Joon Ahn, Mo Wang*, Xuebo Hu* Ethanol and Methanol Can Improve Huperzine A Production From Endophytic Colletotrichum gloeosporioides ES026. Plos One 2013, 8:e61777. 11. Xuebo Hu, P. Saha, Xiaoyue Chen, Dogeun Kim, Mahesh Devarasetty, Raghavan Varadarajan, Moonsoo Jin. Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions. J. Am. Chem. Soc. 2012, 134:14642-14645. 12. Jacque M Tremblay, Chueh-Ling Kuo, Claudia Abeijon, Jorge Sepulveda, George Oyler, Xuebo Hu, Moonsoo M Jin, Charles B Shoemaker. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon, 2010,56:990-998. 13. Xuebo Hu, Sungkwon Kang, Craig Lefort, Minsoo Kim, Moonsoo Jin. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc. Natl. Acad. Sci. U. S. A. 2010,107: 6252-6257. 14. Xuebo Hu, Sungkwon Kang, Xiaoyue Chen, Shoemaker CB, Moonsoo Jin. Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. J Biol Chem. 2009 12;284(24):16369-76. 15. Xuebo Hu, Huijuan Zhang, Guojun Li, Yuxia Yang, Zhong Zheng, Fengming Song. Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009, 28(6):985-95. 16. Chaozheng Zhang , Yueyong Liu , Liyue Liu , Zhiyong Lou, Hongyan Zhang, Hongqin Miao, Xuebo Hu, Yanping Pang, Bingsheng Qiu. Rice black streaked dwarf virus P9-1, an alpha-helical protein, self-interacts and forms viroplasms in vivo. J Gen Virol. 2008 89:1770-1776. 17. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular characterization and expression analysis of a rice protein phosphatase 2C gene, OsBIPP2C1, and overexpression in transgenic tobacco conferred enhanced disease resistance and abiotic tolerance. Physiol Plant. 2006,127: 225-236. 18. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao, Bingsheng Qiu, Zihe Rao, Po Tien. Structural characterization of Mumps virus fusion protein core. Biochem. Biophys. Res. Commun. 2006, 348:916-922. 19. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular cloning and expression of rice OsTVLP1, encoding a protecin with similarity to TGF-belta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins. DNA Seq. 2006 17(2):152-158. 20. Yong Li, Mingyu Wu, Houhui Song, Xuebo Hu, Bingsheng Qiu. Identification of a tobacco protein interacting with tomato mosaic virus coat protein and facilitating long-distance movement of virus. Arch Virol 2005, 150:1993-2008. 21. Yueyong Liu, Yong Li, Liyue Liu, Xuebo Hu, Bingsheng Qiu. Design of vectors for efficient integration and transformation in Hansenula polymorpha. Biotech Lett. 2005, 27(19):1529-1534.