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个人简介

科研项目 国家自然科学基金(青年项目)2017-2019 广东省自然科学基金(博士启动)2015-2018 教育部留学归国人员科研启动基金 2015

研究领域

环境污染物的器官毒性作用机制研究

近期论文

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Du SH, Tan XH, Zhao R, Zhao D, Xue Y, Wang HJ, Xie XL*, Wang Q*. Molecular pathology of cerebral TNF-α, IL-1β, iNOS and Nrf2 in forensic autopsy cases with special regard to deaths due to environmental hazards and intoxication. Forensic Sci Med Pathol. 2017 Dec;13(4):409-416. Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du SH, Xue Y, Xie XL*, Wang Q*. Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. Sci Rep. 2017 May 10;7(1):1691. Wang Q, Wei LW, Xiao HQ, Xue Y, Du SH, Liu YG*, Xie XL*. Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: In vivo and in vitro studies. Food Chem Toxicol. 2017 Jul;105:61-72. Du Y, Jin HN, Zhao R, Zhao D, Xue Y, Zhu BL, Guan DW, Xie XL*, Wang Q*. Molecular Pathology of Pulmonary Edema in Forensic Autopsy Cases with Special Regard to Fatal Methamphetamine Intoxication. J Forensic Sci. 2016 Nov;61(6):1531-1537. Xue Y, Zhao R, Du SH, Zhao D, Li DR, Xu JT, Xie XL*, Wang Q*. Decreased mRNA levels of cardiac Cx43 and ZO1 in sudden cardiac death related to coronary atherosclerosis: a pilot study. Int J Legal Med. 2016 Jul;130(4):915-22. Zhao TL, Xue Y, Tan XH, Qiao DF, Xie XL*,Qi Wang* Fatal Thigh Compartment Syndrome: A Case Report and Review of Literature. J J Foren Sci. 2015, 1(2): 007. Xie XL, Gi M, Fujioka M, Doi K, Yamano S, Tachibana H, Fang H, Kakehashi A, Wanibuchi H*. Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats. Food Chem Toxicol. 2015 Sep;83:193-200. Xie XL, Kakehashi A, Wei M, Yamano S, Takeshita M, Yunoki T, Wanibuchi H*. L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes. Food Chem Toxicol. 2013 Sep;59:137-44. Xie XL, Wei M, Yunoki T, Kakehashi A, Yamano S, Kato M, Wanibuchi H*. Long-term treatment with L-isoleucine or L-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis. Food Chem Toxicol. 2012 Nov;50(11):3934-40. Xie XL, Wei M, Kakehashi A, Yamano S, Okabe K, Tajiri M, Wanibuchi H*. Dammar resin, a non-mutagen, induces oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline. Mutat Res. 2012 Oct 9;748(1-2):29-35. Xie XL, Wei M, Kakehashi A, Yamano S, Tajiri M, Wanibuchi H*. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways. Toxicol Sci. 2012 Feb;125(2):392-400.

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