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研究领域

1.抗炎免疫新药发现;2.肿瘤免疫机理研究; 3.癌症检测探针的研发;4.化学合成

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Zheng, L.; Zhang, L.; Huang, J.; Nandakumar, K.S.; Liu, S.W.*;Cheng, K.*“Potential treatment methods targeting 2019-nCoV infection”.Eur. J. Med. Chem.2020,205, 112687. (IF 5.57,药学小类I区) doi:10.1016/j.ejmech.2020.112687 Chen, Y.L.;Cheng. K.*“Advances of biological-camouflaged nanoparticles delivery system”.Nano Res.2020, doi:10.1007/s12274-020-2931-5. (IF 8.18,大类1区) Wen, K.M.; Fang, X.C.; Yang, J.L. Yao, Y.F.; Nandakumar, K. S.; Salem, M. L.;Cheng. K.*“Recent Research on Flavonoids and their Biomedical applications”.Curr. Med. Chem.2020, 27, 1-25. doi:10.2174/0929867327666200713184138. (IF 4.18,药学3区) Tang, X.S.; Yang, J.; Wang, W.Q.; Zeng, Y.N.; Li, J.P.; Lin S.S.; Nandakumar, K.S.;Cheng, K.* “Immunotherapy for Treating Methamphetamine, Heroin and Cocaine Use Disorders”.Drug Discov. Today2020,25, 610-619. doi:10.1016/j.drudis.2019.07.009. (IF 7.32,小类I区) Lin, Y.; Fan, J.*; Ruan, L.; Bi, J.; Yan, Y.; Wang, T.; Gao, H. *; Yao X.S.;Cheng, K.*; Zhang, W.G.* “Semi-preparative separation of dihydromyricetin enantiomers by supercritical fluid chromatography and determination of anti-inflammatory activities”.J. Chromatogr. A.2019,1606, 460386 (IF 4.05,小类I区) Yang, J.; Tang, X.S.; Nandakumar, K.S.;Cheng, K.* “Autophagy induced by STING, an unnoticed and primordial function of cGAS”.Cell. Mol. Immunol.2019,16, 683-684. doi: 10.1038/s41423-019-0240-2. (IF 8.48,大类1区) Bi, J.J.; Wang, W.Q.; Du, J.X.; Chen, K.;Cheng, K.* “Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents”.Eur. J. Med. Chem.2019,179, 233-245. (IF 5.57,药学小类I区) doi:10.1016/j.ejmech.2019.06.059 Cen, X.; Zhu, G.Z.; Yang, J.J.; Guo, J.Y.; Jin, J.B.; Nandakumar, K.S.; Yang, W.; Yin, H.; Liu, S.W.;Cheng, K.* “TLR1/2 Specific Small-molecule Agonist Suppresses Leukemia cancer cell growth by stimulating Cytotoxic T lymphocytes”.Adv. Sci.2019,6, 1802042. (IF 15.84,大类1区)doi:10.1002/advs.201802042 Chen, Z.; Cen, X.; Yang, J.; Lin, Z.; Liu, M.;Cheng, K.* “Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors”.Eur. J. Med. Chem.2019,169, 42-52. (IF 5.57,药学小类I区) doi:10.1016/j.ejmech.2019.02.067 Chen, Z.; Cen, X.; Yang, J.; Tang, X.; Cui, K.;Cheng, K.* “Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from ZINC drug library database”.Chem. Comm.2018, 54, 11411-11414 (IF 5.99,大类1区)doi:10.1039/C8CC06618C Cen, X.;Cheng, K.* “Ter-cell, a new target for hepatocellular carcinoma therapy”. ChemBioChem2018,19, 2254-2256.(IF 2.57,药学3区) doi: 10.1002/cbic.201800410 Cen, X.; Liu, S.W.;Cheng, K.* “The Role of Toll-Like Receptor in Inflammation and Tumor Immunity”.Front. Pharmacol.2018,9, 878.(IF 4.22,药学2区)doi:10.3389/fphar.2018.00878 Bhattacharyya, S.*; Wang, W.; Qin, W.;Cheng, K.; Coulup, S.; Chavez, S.; Raparia, K.; De Almeida, L. M.; Stehlik, C.; Tamaki, Z.; Yin, H.*; Varga, J.* “TLR4-Dependent Fibroblast Activation Drives Persistent Organ Fibrosis in Skin and Lung”.JCI Insight2018,3, e98850.(IF 6.20) Xu, Y.; Chen, S.J.; Cao, Y.; Zhou, P.Z.; Chen, Z.P.;Cheng, K.*“Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents”.Eur. J. Med. Chem.2018,154, 253-266. (IF 5.57,药学小类I区)doi:10.1016/j.ejmech.2018.05.033 Cai, S.Y.;Zhu, G.Z.; Cen, X.H.;Bi J.J.; Zhang, J.R.; Tang, X.S.; Chen, K.;Cheng, K.* “Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors”.Bioorg. Med. Chem.2018,26, 2041-2050. (IF 3.07,医学/药学3区) doi:10.1016/j.bmc.2018.03.001 Zhu, G.Z.; Xu, Y.; Cen, X.H.; Nandakumar, K.S.; Liu, S.W.*;Cheng, K.*“Targeting pattern-recognition receptors to discover new small molecule immune modulators”.Eur. J. Med. Chem.2018,154, 82-92. (IF 5.57,药学小类I区)doi:10.1016/j.ejmech.2017.12.026 Xu, Q.; Zhu, G.Z.; Li, J.;*andCheng, K.;* “Development of Antibacterial Drugs by Targeting Toll-Like Receptors”,Curr. Top. Med. Chem.2017,17,270-277. (IF 3.21,医学/药学3区)doi:10.2174/1568026616666160829161639 Bajo, M.; Montgomery, S. E.; Cates, L. N.; Nadav, T.; De Lucchi, A.;Cheng, K.; Yin, H.; Crawford, E. F.; Roberts, A. J.; Roberto, M.; "Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol Drinking Behavior in Alcohol Dependent Mice",Alcohol Alcohol.2016,51, 541-548. (IF 2.07) Yan, L.; Liang, J.; Yao, C.; Wu, P.; Zeng, X.;Cheng, K.; Yin, H.; "Pyrimidine Triazole Thioether Derivatives as Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitors",ChemMedChem2016,11, 822-826 (IF 3.12,医学/药学3区) Xu, Q.; Jiang, S.;Cheng, K.; Yin, H.; "Progress in Immunomodulators Targeting Toll-Like Receptors",Prog. Pharm. Sci.2016,40, 42-55 . [Link]

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