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个人简介

学习经历: 1989.9-1993.7南昌大学,食品化学,学士 1993.9-1996.4华南理工大学,发酵工程,硕士 1999.9-2002.7第一军医大学,药理学,博士 2002.4-2014.12纽约血液中心,博士后(ResearchFellow) 工作经历: 1996.4-1998.9第一军医大学药物研究所,助教 1998.9-2004.8第一军医大学药物研究所,讲师 2004.8-2005.12南方医科大学药学院,讲师 2005.1-2005.5纽约血液中心,助理研究员(AssistantMember) 2005.12-南方医科大学药学院,教授 2008.10-2009.1德国乌尔姆大学,访问教授 2009.6-2009.10英国伦敦大学,高级研究学者 2010.1-南方医科大学药学院,免疫与生化药理学科主任 2012.12-南方医科大学药学院,院长 主要获奖情况: 1.广东省高等学校“珠江学者”特聘教授,广东省教育厅,2010; 2.YoungResearchNewStarScientistAward,Pfizer/科学新闻/Elsvier,2010; 3.广东省科技进步二等奖。B17-0-2-01。广东省科学技术委员会,2008; 4.广东省高等学校“千百十工程”国家级培养对象,广东省教育厅,2008; 5.中国药理学会青年药理学工作者奖,中国药理学会,2007年; 6.“新世纪优秀人才”,国家教育部,2007。 主要科研课题: 1.国家自然科学基金-广东联合基金重点项目。U1301224。以血凝素蛋白保守功能区为新靶点的小分子天然来源流感病毒进入抑制剂研究。2014.1~2017.12。 2.国家重大新药创制专项课题。2014ZX09509001-004。中药祛毒增宁胶囊及与HAART联合治疗HIV/AIDS的临床研究。2014.1~2016.12。 3.国家自然科学基金项目。31370781。HIV包膜蛋白gp120降解多肽形成淀粉样纤维结构促进HIV感染的研究。2014.1~2017.12。 4.国家自然科学基金-广东省联合基金重点项目。U0832001。以HIV包膜蛋白为靶点的病毒进入抑制剂及其分子机制。2009.1~2012.12。 5.国家科技重大专项课题。2009ZX09103-011。以HIVgp41为靶点的四氮唑芳基杂环类新型抗艾滋病药物研究。2009.1~2010.12。 6.国家自然科学基金委海外、港澳青年合作基金(国内合作者)。30729001。2008.1~2010.12。 7.国家自然科学基金项目。30772602。靶向血凝素跨膜亚基HA2的H5N1禽流感病毒进入抑制剂的研究。2008.1~2010.12。 8.国家自然科学基金项目。30672496。基于T-20新作用机制的HIV融合抑制剂药物新靶点的研究。2007.1~2009.12。 9.教育部高等学校科技创新工程重大项目培育基金。706047。多酚类小分子化合物预防和治疗艾滋病的研究。2007.1~2008.12。 10.教育部新世纪优秀人才计划。NCET-06-0753。2007.1~2009.12。

研究领域

研究方向: 1.病毒进入抑制剂的高通量药物筛选研究 2.膜融合的作用机理及膜融合抑制剂的作用机制研究 3.预防HIV性传播的杀微生物剂研究 4.病毒感染的免疫药理学研究

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

代表性论文: 1.TanSY,DuanH,XunTR,CiW,QiuJY,YuF,ZhaoXY,WuLX,LiL,LuL,JiangSB,LiuSW*.HIV-1ImpairsHumanRetinalPigmentEpithelialBarrierFunction:PossibleAssociationwiththePathogenesisofHIV-associatedRetinopathy.LaboratoryInvestigation.2014,inpress. 2.TanSY,LiL,LuL,PanCG,LuH,OksovY,TangXJ,JiangSB*,LiuSW*.PeptidesDerivedfromHIV-1gp120Co-receptorBindingDomainFormAmyloidFibrilsandEnhanceHIV-1Infection.FEBSLetters.2014,inpress. 3.YuF,LuL,LiuQ,YuXW,WangLL,HeE,ZouP,DuLY,SandersRW,LiuSW*,JiangSB*.ADS-J1inhibitsHIV-1infectionandmembranefusionbytargetingthehighlyconservedpocketinthegp41NHR-trimer.BiochimicaetBiophysicaActa-Biomembrane,2014;1838(5):1296-1305. 4.GuCP,YuFL,YuL,HeXY,ZhongDS,HeLG,LvLY,XieL,LiuSW*.AnovelsyntheticdibenzocyclooctadienelignananalogXLYF-104-6attenuateslipopolysaccharide-inducedinflammatoryresponseinRAW264.7macrophagecellsandprotectsBALB/cmicefromsepsis.EuropeanJournalofPharmacology,2014;729(1):22-29 5.ZhouZZ,GuCP,DengYH,YanGH,LiXF,YuL,ChenWH*,LiuSW*.Synthesis,selectivecytotoxicitiesandprobablemechanismofactionof7-methoxy-3-arylflavone-8-aceticacids.Bioorganic&MedicinalChemistry,2014;22(5):1539-1547 6.HeLG,LiXL,ZengXZ,DuanH,WangS,LeiLS,LiXJ*,LiuSW*.SinomenineinducesapoptosisinRAW264.7cell-derivedosteoclastsviacaspase-3activation.ActaPharmacologicaSinica.2014;35(2):203-10 7.YuFL,HeXY,GuCP,OhkoshiE,WangLT,LaiCY,YuL,WangSB,Morris-NatschkeSL,LeeKX,LiuSW*,XiL*.DiscoveryofNovelAntitumorDibenzocyclooctatraeneDerivativesandRelatedBiphenylsasPotentInhibitorsofNF-kappaBSignalingPathway.Bioorganic&MedicinalChemistry,2014;22(1):325-33. 8.ZhuQH,HuangL,SuJR,LiuSW*.Asensitiveandvisiblefluorescence-turn-onprobefortheCMCdeterminationofionicsurfactants.ChemicalCommunications,2014;50(9):1107-1109 9.YuL,LiuSW*.AutophagycontributestomodulatingthecytotoxicitiesofBcl-2homologydomaim-3mimetics.SeminarsinCancerBiology,2013,23(6PtB):553-60 10.SongDS,XuHH*,LiuSW*.TheoreticalStudiesoftheInteractionsbetweenHemagglutininoftheInfluenzaVirusanditsSmallMoleculeLigands.JournalofMolecularModeling,2013;19(12):5561-8. 11.QiuJ,AshkenaziA,LiuS,ShaiY.StructuralandFunctionalPropertiesoftheMembranotropicHIV-1Gp41LoopRegionareModulatedbyitsIntrinsicHydrophobicCore.JournalofBiologicalChemistry.2013,288(40):29143-29150 12.LiXJ,HeLG,HuYP,DuanH,LiXL,TanSY,ZouM,GuCP,YuL,XuJK,LiuSW*.SinomeninesuppressesosteoclastformationandMycobacteriumtuberculosisH37Ra-inducedbonelossbymodulatingRANKLsignalingpathways.PLoSOne,2013,8(9):e74274 13.HuangL,SuJR,ZhongDS,LiuRY,WangHB,YuL,ZhuQH*,LiuSW*.Copper-InducedFluorescenceEnhancementandParticle-SizeDecrease.RSCAdvances,2013,3(32),13286-13292 14.LvLY,ZhengSC,CaiXT,ChenZP,ZhuQH*,LiuSW*.Developmentoffour-componentsynthesisoftetra-andpentasubstitutedpolyfunctionaldihydropyrroles:freepermutationandcombinationofaromaticandaliphaticAmines.ACSCombinatorialScience.2013;15(4):183-92 15.TanSY,LuL,LiL,LiuJX,OksovY,LuL,JiangSB*,LiuSW*.Polyanioniccandidatemicrobicidesacceleratetheformationofsemen-derivedamyloidfibrilstoenhanceHIV-1infection.PLoSOne,2013,8(3):e59777IF:3.730 16.LiL,QiuJY,LuL,AnSL,QiaoP,JiangSB,LiuSW*.3-Hydroxyphthalicanhydride-modifiedhumanserumalbuminasamicrobicidecandidateinhibitsHIVinfectionbyblockingviralentry.JournalofAntimicrobialChemotherapy.2013;68(3):573-576 17.YangJ,LiMM,ShenXT,LiuSW*.InfluenzaAvirusentryinhibitorstargetingthehemagglutinin.Viruses,2013;5(1):352-373. 18.BaiY,XueHF,WangK,CaiLF,QiuJY,BiSY,LaiLH,ChenMS,LiuSW*,LiuKL*.CovalentfusioninhibitorstargetingHIV-1gp41deeppocket.AminoAcids,2013;44(2):701-713 19.ChenMH,YuL,GuCP,ZhongDS,WuSG,LiuSW*.Celecoxibantagonizesthecytotoxiceffectofcisplatininhumangastriccancercellsbydecreasingintracellularcisplatinaccumulation.CancerLetters,2013;329:189-196 20.ZhuQH,HuangL,ChenZP,ZhengSC,LvLY,ZhuZB,CaoDL,JiangHF*,LiuSW*.ANovelSeriesofC-6UnsubstitutedTetrahydropyrimidines:ConvenientOne-PotChemoselectiveSynthesis,Aggregation-InducedandSize-IndependentEmissionCharacteristics.Chemistry:AEuropeanJournal.2013;19(4):1268-1280 21.YangJ,LiL,JinH,TanSY,QiuJY,YangL,DingYQ,JiangZH,JiangSB,LiuSW*.VaginalgelformulationbasedontheaflavinderivativesasamicrobicidetopreventHIVsexualtransmission.AIDSResearchandHumanRetroviruses,2012,28(11):1498-508 22.ZhuZB,LiRM,XiaoGK,ChenZP,YangJ,ZhuQH,LiuSW*.Design,synthesisandstructure-activityrelationshipofnovelinhibitorsagainstH5N1hemagglutinin-mediatedmembranefusion.EuropeanJournalofMedicinalChemistry.2012,57:211-6. 23.LiRM,SongDS,ZhuZB,XuHH,LiuSW*.AninducedpocketforthebindingofpotentfusioninhibitorCL-385319withH5N1influenzavirushemagglutinin.PLoSOne,2012,7(8):e41956 24.ZhuQH,GaoLX,ChenZP,ZhengSC,SuHF,LiJ*,JiangHF*,LiuSW*.Anovelclassofsmall-moleculecaspase-3inhibitorspreparedbymulticomponentreactions.EuropeanJournalofMedicinalChemistry.2012,54:232-238. 25.ZengYL,LiW,LiJT,WangJJ,ZhouB,ZhangJ,LiuSW*,WuYS,HouJL,ZhouYP*.HepatitisCvirusaminoacidsequencediversitycorrelateswiththeoutcomeofcombinedinterferon/ribavirintherapyinChinesepatientswithchronichepatitisC.ArchiveofVirology.2012,157(1):1113-1121. 26.JiaQY,JiangXF,YuF,QiuJY,KangXY,CaiLF,LiL,ShiWG,LiuSW*,JiangSB*,LiuKL*.ShortcyclicpeptidesderivedfromtheC-terminalsequenceofα1-antitrypsinexhibitsignificantanti-HIV-1activity.Bioorganic&MedicinalChemistryLetters.2012,22(7):2393-5. 27.LiXJ,HuYP,HeLG,WangS,ZhouH,LiuSW*.IcaritininhibitsTcellactivationandprolongsskinallograftsurvivalinmice.InternationalImmunopharmacology.2012;13(1):1-7. 28.YangJ,LiL,TanSY,JinH,QiuJY,MaoQC,LiRM,XiaCL,JiangZH,JiangSB,LiuSW*.AnaturaltheaflavinspreparationinhibitsHIV-1infectionbytargetingtheentrystep:potentialapplicationsforpreventingHIV-1infection.Fitoterapia,2012;83(2):348-355 29.YuL,ChenMH,LiZJ,WenJ,FuJH,GuoG,JiangY,WuSW,ChoCH,LiuSW*.Celecoxibantagonizesthecytotoxicityofcisplatininhumanesophagealsquamouscellcarcinomacellsbyreducingintracellularcisplatinaccumulation.MolecularPharmacology,2011;79(3):608-617 30.LiL,TanSY,LuH,LuL,YangJ,JinH,LiuSW*,JiangS*.Combinationsof3-HydroxyphthalicAnhydride-modifiedOvalbuminwithAntiretroviralDrug-basedMicrobicideCandidatesDisplaySynergisticandComplementaryEffectsagainstHIV-1Infection.JournalofAcquiredImmuneDeficiencySyndromes,2011;56(5):384-392 31.LiuSW*,LiRM,ZhangRT,ChanC,XiBM,ZhuZB,YangJ,PoonV,ZhouJ,ChenM,MünchJ,KirchhoffF,PleschkaS,HaarmannT,DietrichU,PanCG,DuLY,JiangSB,ZhengBJ*.CL-385319inhibitsH5N1avianinfluenzaAvirusinfectionbyblockingviralentry.EuropeanJournalofPharmacology,2011;660(2-3):460-467 32.ShangSF,TanSY,LiKB,WuJ,LinHN,LiuSW*,DengYQ*.Glu659LeusubstitutionofrecombinantHIVfusioninhibitorC52LinducessolubleexpressioninE.coliwithequivalentanti-HIVpotency.ProteinEngineering,Design&Selection,2011;24(7):545-551 33.XiaCL,LuoDX,YuXL,JiangSB*,LiuSW*.HIV-associateddementiaintheeraofhighlyactiveantiretroviraltherapy(HAART).MicrobesandInfection,2011;13:419-425 34.ZhouZZ,ZouM,ZhouJ,ZhouCQ,DengYH,ChenMH,GuCP,JiangZH,ChenWH*,LiuSW*.Synthesis,CytotoxicitiesandDNA-BindingAffinitiesofBenzofuran-3-olsandTheirFusedAnalogs.ChemicalandPharmaceuticalBulletin,2011;59(8):1057-1061. 35.LiL,QiaoP,YangJ,TanS,LuH,ZhangX,ChenX,WuS,JiangS*,LiuS*.Maleicanhydride-modifiedchickenovalbuminasaneffectiveandinexpensiveanti-HIVmicrobicidecandidateforpreventionofHIVsexualtransmission.Retrovirology,2010,7(1):37 36.LiL,HeL,TanS,GuoX,LuH,QiZ,PanC,AnX,JiangS*,LiuS*.3-HydroxyphthalicAnhydride-modifiedChickenOvalbuminExhibitsPotentandBroadAnti-HIV-1Activity:aPotentialMicrobicideforPreventingSexualTransmissionofHIV-1.AntimicrobialAgentsandChemotherapy,2010,54(5):1700-1711 37.WangHT,QiZ,GuoA,MaoQC,LuH,AnXL,XiaCL,LiXJ,DebnathAK,WuSG,LiuSW*,JiangSB*.ADS-J1inhibitsHIV-1entrybyinteractingwiththegp41pocketregionandblockingthefusion-activegp41coreformation.AntimicrobialAgentsandChemotherapy,2009;53(12):4987-4998 38.DuLY,HeYX,ZhoYS,LiuSW,ZhengBJ,JiangSB.ThespikeproteinofSARS-CoV—atargetforvaccineandtherapeuticdevelopment.NatureReviewofMicrobiology,2009;7(3):226-236 39.LiuSW*,JingW,ChengB,LuH,SunJ,YanX,NiuJ,FarmarJ,WuS,JiangS.HIVgp41c-terminalheptadrepeatcontainsmulti-functionaldomains:relationtomechanismsofactionofanti-HIVpeptides.JournalofBiologicalChemistry,2007;282(13):9612-9620 40.LiuSW,WuSG,JiangSB.HIVentryinhibitorstargetinggp41:frompolypeptidestosmall-moleculecompounds.CurrentPharmaceuticalDesign,2007;13(2):143-162. 41.JiangSB,LiuSW,StoneA.ChinaneedssafeandeffectivemicrobicidesforpreventingthesexualtransmissionofHIV.LancetInfectiousDiseases,2006;6(11):681-682 42.LiuSW,LuH,NiuJ,XuY,WuS,JiangS.DifferentfromtheHIVfusionInhibitorC34,theanti-HIVdrugFuzeon(T-20)inhibitsHIV-1entrybytargetingmultiplesitesingp41andgp120.JournalofBiologicalChemistry,2005;260(12):11259-11273 43.LiuSW,LuH,NeurathAR,JiangS.Combinationofcandidatemicrobicidescelluloseacetate1,2-benzenedicarboxylateandUC781resultsinsynergisticandcomplementaryeffectsagainsthumanimmunodeficiencyvirustype1infection.AntimicrobialAgentsandChemotherapy,2005;49(5):1830-1836 44.LiuSW,LuH,ZhaoQ,HeY,NiuJ,DebnathAK,WuS,JiangS.TheaflavinderivativesinblackteaandcatechinderivativesingreenteainhibitHIV-1entrybytargetinggp41.BiochimicaetBiophysicaActa-generalsubjects,2005;1723(1-3):270-281 45.LiuSW,XiaoGF,ChenYB,HeYX,NiuJK,EscalanteCR,XiongHB,FarmarJ,DebnathAK,TienP,JiangSB.Interactionbetweentheheptadrepeat1and2regionsinspikeproteinofSARS-associatedcoronavirus:Implicationforvirusfusogenicmechanismandidentificationoffusioninhibitors.Lancet,2004;363(9413):938-947 46.LiuSW,JiangSB.HighthroughputscreeningandcharacterizationofHIV-1entryinhibitorstargetinggp41:theoriesandtechniques.CurrentPharmaceuticalDesign,2004;10(15):1827-1843 47.LiuSW,ZhaoQ,JiangS.DeterminationoftheHIV-1gp41fusogeniccoreconformationmodeledbysyntheticpeptides:applicableforidentificationofHIV-1fusioninhibitors.Peptides,2003;24(9):1303-1313 48.LiuSW,Boyer-ChatenetL,LuH,JiangS.Rapidandautomatedfluorescence-linkedimmunosorbentassayforhighthroughputscreeningofHIV-1fusioninhibitorstargetinggp41.JournalofBiomolecularScreening,2003;8(6):685-693 49.LiuSW,JiangS,WuZ,LvL,ZhangJ,ZhuZ,WuS.IdentificationofaninhibitoroftheHIV-1gp41six-helixbundleformationfromextractsofChinesemedicalherbsPrunellaVulgarisandRhizomaCibotte.LifeSciences,2002;71:1779-1791 50.LiuSW,LuH,ZhaoQ,HeY,NiuJ,DebnathAK,WuS,JiangS.TheaflavinderivativesinblackteaandcatechinderivativesingreenteainhibitHIV-1entrybytargetinggp41.BiochimicaetBiophysicaActa-generalsubjects,2005;1723(1-3):270-281 51.LiuSW,XiaoGF,ChenYB,HeYX,NiuJK,EscalanteCR,XiongHB,FarmarJ,DebnathAK,TienP,JiangSB.Interactionbetweentheheptadrepeat1and2regionsinspikeproteinofSARS-associatedcoronavirus:Implicationforvirusfusogenicmechanismandidentificationoffusioninhibitors.Lancet,2004;363(9413):938-947 52.LiuSW,JiangSB.HighthroughputscreeningandcharacterizationofHIV-1entryinhibitorstargetinggp41:theoriesandtechniques.CurrentPharmaceuticalDesign,2004;10(15):1827-1843 53.LiuSW,ZhaoQ,JiangS.DeterminationoftheHIV-1gp41fusogeniccoreconformationmodeledbysyntheticpeptides:applicableforidentificationofHIV-1fusioninhibitors.Peptides,2003;24(9):1303-1313 54.LiuSW,Boyer-ChatenetL,LuH,JiangS.Rapidandautomatedfluorescence-linkedimmunosorbentassayforhighthroughputscreeningofHIV-1fusioninhibitorstargetinggp41.JournalofBiomolecularScreening,2003;8(6):685-693 55.LiuSW,JiangS,WuZ,LvL,ZhangJ,ZhuZ,WuS.IdentificationofaninhibitoroftheHIV-1gp41six-helixbundleformationfromextractsofChinesemedicalherbsPrunellaVulgarisandRhizomaCibotte.LifeSciences,2002;71:1779-1791

学术兼职

主要学术任职: 1.中国药理学会理事 2.中国药理学会抗炎免疫药理专业委员会副主任委员 3.广东省药理学会副理事长 4.广东省新药筛选重点实验室主任 5.广东省青年科学家学会理事 6.广东省高性能计算学会生物医药专业委员会主任委员 7.ActaPharmacologicaSinica编委 8.中国药理学通报编委

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