梁新乐 - 浙江工商大学 - 食品与生物工程学院

个人简介

1996年毕业于天津科技大学，发酵工程硕士。2002年获浙江大学生物化工博士学位。2000年，英国Cranfield University交流杨梅致腐真菌研究，2010-2011年美国Rensselaer Polytechnic Institute研究访问--细菌粘多糖基因工程改造。2016-2017年美国Cornell University研究访问--蛋白质表达机制调控。浙江省151人才。

研究领域

（1）食品微生物菌种资源及产品开发。以醋酸菌、嗜甲醇菌、酵母菌为对象，采用基因组学与蛋白组学等手段从群体感应、信号调控及膜结构生物学方面阐述工业菌种的抗逆性分子机制，改良工业菌种及产品开发品；生产新型高活性高价值代谢产物如虾青素、吡咯喹啉醌等（2）蛋白质表达机制调控及应用研究，探索、改良蛋白的可溶性表达及跨膜运输机制，探索目标蛋白的定向进化和糖基化修改；（3）食品微生物杀菌技术研究，通过解析细菌构造及生理代谢，研发改良食品微生物杀菌机理及工艺优化

近期论文

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Yuanyuan Zhu, Ning Zang, Hong Zhang, Yudong Li, Wei Feng, Ye Liu, Xinle Liang*. Comparative secretome analysis of industrial Aspergillus oryzae isolates utilized in soybean paste fermentation. Int J Food Microbiol, 2016, under review. 夏凯,朱军莉,梁新乐. 醋酸菌耐酸机理及其群体感应研究新进展.微生物学报,2016 （已录用） Kai Xia, Ning Zang, Junmei Zhang, Hong Zhang, Yudong Li, Ye Liu, Wei Feng, Xinle Liang*. New insights of acetic acid resistant mechanisms of Acetobacter pasteurianus based on iTRAQ-dependent quantitative proteomic Analysis. Inter J Food Microbiol, 2016, 238:241-251. Xia, K., Li, Y., Sun, J., Liang, X. Comparative genomics of Acetobacter pasteurianus Ab3, an acetic acid producing strain isolated from Chinese traditional rice vinegar Meiguichu. PLoS One 2016, 11, e0162172. Wang Zhe, Ning Zang, Jieyan Shi, Wei Feng, Ye Liu, Xinle Liang*.Comparative proteome of Acetobacter pasteurianus Ab3 during the high acidity rice vinegar fermentation. Appl Biochem Biotechnol, 2015, 177:1573-1 夏凯,梁新乐,李余动. 醋酸菌中CRISPR 位点的比较基因组学与进化分析. 遗传, 2015, 37(12):1242-1250 Tingting Zhang, Si Chen, Xinle Liang, Hong Zhang*. Development of a mass-spectrometry-based lipidomics platform for the profiling of phospholipids and sphingolipids in brain tissues. Anal Bioanal Chem 2015, 407: 6543–6555. Jieyan Shi, Ye Liu, Wei Feng, Xiong Chen, Yanglin Zhu, Xinle Liang*. Investigation of bacterial diversity in traditional Meigui rice vinegar by PCR-DGGE method. Lecture Notes in Electrical Engineering, 2014, Vol 249, 249:417-425 黄旭镇; 朱军莉; 赵二科; 梁新乐. LC-MS/MS检测水产品源致病菌和腐败菌群体感应AHLs信号分子.水产学报, 2014,7:1040-1046 胡向东; 潘玲燕; 章祺; 叶茂; 梁新乐. 复合诱变选育高产虾青素的红法夫酵母菌株. 食品与发酵工业,2014, 10:58-62 Xing-An Lv, Ying-Yan Jin, Yu-Dong Li, Hong Zhang, XinLe Liang*. Genome shuffling of Streptomyces viridochromogenes for improved production of avilamycin. Appl Microbiol Biotechnol 2013, 97:641–648 Shanshan Zhao, Feishu Cao, Hong Zhang, Lei Zhang, Fuming Zhang, Xinle Liang*. Structural characterization and biosorption of exopolysaccharides from Anoxybacillus sp. R4-33 isolated from radioactive radon hot spring. 2014. 172:2732-2746 Yudong Li*, Wei Chen, Yugang Shi, Xinle Liang*. Molecular cloning and evolutionary analysis of the HOG-signaling pathway genes from Saccharomyces cerevisiae rice wine isolates. Biochem Genet.2013, 2013, 51(3-4):296-305 Zhi Wang, Mei Yan, Xiong Chen*, Dongsheng Li, Li Qin, Zhijun Li, Juan Yao, Xinle Liang. Mixed culture of Saccharomyces cerevisiae and Acetobacter pasteurianus for acetic acid production. Biochem Eng J, 2013,79:41-45 Joshua J. Ziarek, Christopher T. Veldkamp, Fuming Zhang, Nathan J. Murray, Gabriella A. Kartz, Xinle Liang, Jidong Su, John E. Baker, Robert J. Linhardt, and Brian F. Volkman. Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus. The J of Biological Chem, 2013, 288(1):737-746 Chao Wang, Gongzhen Wu, Yudong Li, Yinyin Huang, Fuming Zhang, Xinle Liang* .Genome shuffling of Penicillium citrinum for enhanced production of nuclease P1. Appl Biochem Biotechnol, 2013,170:1533-1545 Fuming Zhang*, Xinle Liang, Dennis Pu, Kasim I. George, Paul J. Holland, Scott T.R. Walsh, Robert J. Linhardt*. Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR. Biochimie, 2012, 94:242-249