满淑丽 - 天津科技大学 - 生物工程学院

个人简介

主讲课程：本科生：天然药物学、免疫学、生物制药工艺学等。研究生：天然药物学、免疫学等。科研情况 [1]国家自然科学基金项目：基于肿瘤微环境干预的重楼皂苷抗转移性肺癌作用机制及物质基础研究，项目负责人，2017-2020. [2]国家自然科学基金项目：基于代谢调控网络干预的重楼总皂苷组分配伍机制研究，项目负责人，2013-2015. [3]天津市自然科学基金项目：基于细胞周期阻滞的楼黄配伍作用机制研究，项目负责人，2013-2016.

研究领域

[1]天然产物提取分离及活性开发 [2]中药成分鉴定及体内外代谢研究 [3]中药组方配伍机制研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]ManSL,LiJ,QiuPY,etal.Inhibitionoflungcancerindiethylnitrosamine-inducedmicebyRhizomaparidissaponins.MolecularCarcinogenesis.2017. [2]QiuPY,SunJC,ManSL*,etal.CurcuminattenuatesN-nitrosodiethylamineinducedliverinjuryinmicebyutilizingthemethodofmetabonomics.JAgricFoodChem.2017. [3]QiuPY,ManSL*,LiJ,etal.Overdosetakingcurcumininitiatingtheunbalancedstateofbodies.JAgricFoodChem.2016;64:2765-2771. [4]ManSL,MaJ,WangCX,etal.ChemicalcompositionandhypoglycemiceffectofpolyphenolsextractsfromLitchichinensisseeds.JFunctFoods.2016;22:313-24. [5]LiuJ,LiuZ,ManSL*,etal.Inhibitionofurethane-inducedlungcarcinogenesisinmicebyRhizomaparidissaponinsinvolvedEGFR/PI3K/Aktpathway.RSCAdvances.2016;6:92330-92334. [6]LiJ,ManSL*,QiuPY,etal.ToxicologicalrisksofRhizomaParidissaponinsinratsinvolvedNF-κBandNrf2signaling.RSCAdvances.2016;6:31889-31897. [7]QiuPY,ManSL*,YangH,etal.MetabolicregulatorynetworkalterationsrevalsdifferenttherapeuticeffectsofcisplatinandRhizomaparidissaponinsinLewispulmonaryadenomamice.RSCAdvances.2016,6,115029-115038. [8]ManSL,LiYY,FanW,GaoWY,LiuZ,LiN,ZhangY,LiuCX.CurcumaincreasingantitumoreffectofRhizomaparidissaponinsthroughabsorptiveenhancementofparidissaponins.IntJPharm.2013;454:296-301. [9]ManSL,WangJ,GaoWY,GuoSB,LiYY,ZhangLM,XiaoPG.Chemicalanalysisandanti-inflammatorycomparisonofthecellcultureofGlycyrrhizawithitsfieldcultivatedvariety.FoodChem.2013;136:513-517. [10]ManSL,QiuPY,LiJ,etal.GlobalmetabolicprofilingforthestudyofRhizomaParidisSaponinsinducedhepatotoxicityinrats.EnvironmentalToxicology.2017;32:99-108. [11]LiuJ,ManSL*,LiuZ,etal.AsynergisticantitumoreffectofPolyphyllinIandFormosaninConhepatocarcinomacells.Bioorganic&MedicinalChemistryLetters.2016;26:4970-5. [12]QiuPY,ManSL*,YangH,etal.UtilizationofmetabonomicstoidentifyserumbiomarkersinmurineH22hepatocarcinomaanddeduceantitumormechanismofRhizomaParidissaponins.Chemico-biologicalinteractions.2016;256:55-63. [13]ManSL,LiJ,LiuJ,etal.CurcuminalleviatedthetoxicreactionofRhizomaparidissaponinsina45-daysubchronictoxicologicalassessmentofrats.EnvironmentalToxicology.2016;31:1935-43. [14]ZhangLL,ManSL*,WangYS,etal.ParisSaponinIIinducedapoptosisviaactivationofautophagyinhumanlungcancercells.Chemico-BiologicalInteractions.2016;253:125-133. 15]ManSL,LiJ,FanW,etal.Inhibitionofpulmonaryadenomaindiethylnitrosamine-inducedratsbyRhizomaparidissaponins.JSteroidBiochemMolBiol,2015;154,62-67. [16]ManSL,ChaiHY,QiuPY,etal.Turmericenhancinganti-tumoreffectofRhizomaparidissaponinsbyinfluencingtheirmetabolicprofilingintumorsofH22hepatocarcinomamice.PatholResPract.2015;211:948-54. [17]LiYY,ManSL*,LiJ,etal.TheantitumoreffectofformosaninConHepG2cellasrevealedby1H-NMRbasedmetabolicprofiling.Chemico-BiologicalInteractions.2014;220C:193-9. [18]ManSL,FanW,LiuZ,etal.AntitumorpathwayofRhizomaParidisSaponinsbasedonthemetabolicregulatorynetworkalterationsinH22hepatocarcinomamice.Steroids.2014;84:17-21. [19]ManSL,LiYY,FanW,etal.CombinationtherapyofcyclophosphamideandRhizomaParidisSaponinsonanti-hepatocarcinomamiceandeffectsoncytochromep450enzymeexpression.Steroids.2014;80:1-6. [20]ManSL,FanW,GaoWY,etal.Anti-fibrosisandanti-cirrhosiseffectsofRhizomaparidissaponinsondiethylnitrosamineinducedrats.JEthnopharmacol.2014;151:407-412. [21]ManSL,GuoSB,GaoWY,etal.Identificationofmetabolicprofilingofcellcultureoflicoricecomparedwithitsnativeone.AnalBioanalChem.2013;405:3321-3329. [22]ManSL,GaoWY,WeiCL.AnticancerdrugsfromTraditionaltoxicChinesemedicines.PhytotherRes.2012;26:1449-1465. [23]ManSL,GaoWY,ZhangYJ,etal.FormosaninC-inhibitedpulmonarymetastasisthroughrepressionofmatrixmetalloproteinasesonmouselungadenocarcinoma.CancerBiolTher.2011;11(6):592-598. [24]ManSL,GaoWY,YanYJ,etal.Inhibitionofmatrixmetalloproteinasesrelatedtometastasisbydiosgenylandpennogenylsaponins.JEthnopharmacol.2011;137(3):1221-1227. [25]ManSL,GaoWY,ZhangYJ,etal.IdentificationofchemicalconstituentsinRhizomaParidisSaponinsandtheiroraladministrationinratplasmabyUPLC/Q-TOF/MS.BiomedChromatogr.2011;25(6):712-719. [26]ManSL,GaoWY,etal.Paridissaponinsinhibitingcarcinomagrowthandmetastasisinvitroandinvivo.ArchPharmRes.2011;34(1):43-50. [27]ManSL,GaoWY,ZhangYJ,etal.QualitativeandquantitativedeterminationofmajorsaponinsinParisandTrilliumbyHPLC-ELSDandHPLC-MS/MS.JChromatogrB.2010;878(29):2943-2948. [28]ManSL,GaoWY,ZhangYJ,etal.ChemicalstudyandMedicalapplicationofSaponinsasAnti-cancerAgents.Fitoterapia.2010;81(7):703-714.