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个人简介

刘夫锋,博士,天津科技大学生物工程学院教授。天津市特聘教授,天津市高校学科领军人才,海河学者特聘教授,香江学者。 主讲课程: 本科生:基因工程,生物信息学基础,计算机辅助药物设计与药物信息学 研究生:生物过程的分子模拟 主要教学研究及成果情况 先后主持或参与教改项目2项,参编教材或专著2部,指导国家级大学生创新训练计划1项,指导天津大学大学生创新性实践计划2项。 [1]天津科技大学教育教学改革“创新创业专项”:创新创业教育背景下生物工程专业实验教学内容改革优化研究 [2]天津大学2014年实验教改项目,生物工程专业实验课教学体系的改革与完善,2015.01-2015.12 [3]Y.Sun,Q.-H.Shi,L.Zhang,G.Zhao,F.-F.Liu:Adsorptionandchromatography.Ined.ComprehensiveBiotechnology,Vol.2,Chapter2.47.pp.665-679.Elsevier,2011. [4]贾士儒主编,生物工程专业实验(第二版),中国轻工业出版社,2010 [5]大学生创新训练计划,淀粉样β蛋白质的高效表达和分离纯化-构建阿尔兹海默症的药物筛选平台,国家级,2017.05-2018.04 [6]天津大学大学生创新性实践计划,0.3万,2015.01-2015.12 [7]天津大学大学生创新性实践计划,0.3万,2010.01-2010.12 科研项目情况 [1]天津市应用基础及前沿技术研究计划重点项目:聚集诱导荧光探针-α-突触核蛋白融合体系构建及其在聚集抑制剂筛选中的应用,2018.04-2021.0320万 [2]海河学者特聘教授:蛋白质聚集及其抑制2016.04-2019.03100万 [3]天津市特聘教授启动经费,2017.07-2022.0650万 [4]天津市高校学科领军人才培养计划:淀粉样蛋白质聚集抑制剂开发,2017.09-2020.1060万 [5]国家自然科学基金面上项目:细胞膜表面有机小分子抑制淀粉样β多肽构象转换和聚集的多尺度研究,2016.01-2019.1273万 [6]国家自然科学基金委-香港研究资助局联合科研资助项目:P-gp介导肿瘤外排紫杉醇的抑制:抑制剂结合位点确定和新型P-gp抑制剂的理性设计,2016.01-2019.12100万 [7]国家自然科学基金青年项目:含羟基类渗透剂稳定蛋白质的分子机理研究,2010.01-2012.1220万 [8]博士后基金特别资助(香江学者计划):黄酮类二聚体作为抵抗癌症的多药耐药逆转剂,2013.03-2015.0610万 [9]博士后基金一等资助,精氨酸衍生物抑制蛋白质聚集的分子模拟研究,2013.05-2015.068万 [10]天津市应用基础及前沿技术研究计划,亲和短肽配基的理性设计和高通量筛选,2010.04-2013.0310万 [11]天津大学自主创新基金,P-糖蛋白的多药耐药性及其抑制的分子机理,2010.01-2011.125万 授权发明专利主要有: [1]YanSun,Wei-WeiZhao,Fu-FengLiu,Qing-HongShi.AnovelaffinitypeptidelibraryofIgGconstructedbasedonproteinAaffinitymodelandtheapplicationofthedesignmethodthereof.USAPatent.PTO/AIA/14(03-13). [2]孙彦,赵韦韦,刘夫锋,史清洪.基于蛋白A亲和模型构建免疫球蛋白G的亲和配基多肽库及设计方法方法的应用.专利号:ZL201210561815.8,授权公告日:2015.06.24 获奖情况 先后荣获天津大学本科毕业设计优秀指导教师、HongKongScholarsAnnualSymposium,Bestposter、津大学北洋学者青年骨干教师(第一批)、天津大学第九届青年教师讲课大赛,天津大学三等奖、天津大学第九届青年教师讲课大赛,化工学院一等奖、宝舜奖教金、天津大学大学生创新性实践计划项目优秀指导教师、天津大学本科毕业设计优秀指导教师。

研究领域

[1]生物过程的分子模拟 [2]蛋白质聚集及抑制 [3]酶工程

近期论文

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[1]N.Xiong,X.-Y.Dong,J.Zheng,F.-F.Liu*,andY.Sun*.DesignofLVFFARKandLVFFARK-functionalizednanoparticlesforinhibitingamyloidβ-proteinfibrillationandcytotoxicity,ACSAppliedMaterials&Interfaces,2015,7(10):5650-5662,SCI1区,Impactfactor:8.097 [2]JunyingWang,YingZhang,XingjiWang,JinzhaoShang,YuLi,HuituZhang,FupingLu*,F.-F.Liu*.Biochemicalcharacterizationandmolecularmechanismofaciddenaturationofanovelα-amylasefromAspergillusniger,BiochemicalEngineeringJournal,2018,137:222-231.SCI2区,Impactfactor:3.226 [3]H.Qin,Z.Zhu,Z.Ma,P.Xu,Q.Guo,S.Li,J.Wang,S.Mao,F.-F.Liu*,F.-P.Lu*.Rationaldesignofcholesteroloxidaseforefficientbioresolutionofcholestaneskeletonsubstrates,ScientificReports,2017,7:16375,SCI3区,Impactfactor:4.122 [4]Y.-L.Tu,S.Ma,F.-F.Liu*,Y.Sun,X.-Y.Dong*.HematoxylinSuppressesAmyloidβ-ProteinAggregationandReducesAmyloidCytotoxicity,TheJournalofPhysicalChemistryB,2016,120(44),11360–11368.SCI2区,Impactfactor:3.603 [5]N.Zhang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.Synergisticinhibitionofacid-inducedproteindenaturationbytrehaloseandNaCl:thermodynamicandkineticstudies,BiochemicalEngineeringJournal,2014,91:231-239,SCI2区,Impactfactor:3.226 [6]W.-J.Du,J.-J.Guo,M.-T.Gao,S.-Q.Hu,X.-Y.Dong,Y.-F.Han,F.-F.Liu*,S.Jiang*,Y.Sun*.Brazilininhibitsamyloidβ-proteinfibrillogenesis,remodelsamyloidfibrilsandreducesamyloidcytotoxicity,ScientificReports,2015,5:7992.SCI2区,Impactfactor:5.578 [7]N.Xiong,X.-Y.Dong,J.Zheng,F.-F.Liu*,andY.Sun*.DesignofLVFFARKandLVFFARK-functionalizednanoparticlesforinhibitingamyloidβ-proteinfibrillationandcytotoxicity,ACSAppl.Mater.Inter.2015,7(10):5650-5662.SCI1区,Impactfactor:7.145 [8]N.Zhang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.Synergisticinhibitionofacid-inducedproteindenaturationbytrehaloseandNaCl:thermodynamicandkineticstudies,BiochemicalEngineeringJournal,2014,91:231-239.SCI2区,Impactfactor:2.467 [9]W.-W.Zhao,F.-F.Liu*,Q.-H.Shi,X.-Y.Dong,andY.Sun*.BiomimeticdesignofaffinitypeptideligandsforhumanIgGbasedonProteinA-IgGcomplex.BiochemicalEngineeringJournal,2014,88:1-11.SCI2区,Impactfactor:2.467 [10]N.Zhang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.CounteractionofTrehaloseonUrea-InducedProteinUnfolding:ThermodynamicandKineticStudies,BiochemicalEngineeringJournal,2013,79(15):120-128.SCI2区,Impactfactor:2.467 [11]J.-J.Guo#,W.-Q.Sun#,F.-F.Liu*.BrazilininhibitstheZn2+-mediatedaggregationofamyloidβ-proteinandalleviatescytotoxicity,JournalofInorganicBiochemistry2017,177:183-189,SCI2区,Impactfactor:3.063 [12]S.-Y.Chang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.MolecularinsightintoconformationaltransmissionofhumanP-glycoprotein,TheJournalofChemicalPhysics,2013,139(22):225102.(Coverpage),SCI2区,Impactfactor:3.122 [13]F.-F.Liu,B.Huang,X.-Y.Dong,andY.Sun*.MolecularBasisfortheDissociationDynamicsofProteinA-ImmunoglobulinG1Complex.PlosOne,2013,8(6):e66935.SCI2区,Impactfactor:4.411 [14]N.Zhang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.Equilibriumandkineticstudiesofthecounteractionoftrehaloseonacid-inducedproteinunfolding.BiochemicalEngineeringJournal,2013,70:188-195.SCI2区,Impactfactor:2.467 [15]N.Zhang,F.-F.Liu*,X.-Y.Dong,andY.Sun*.MolecularInsightintotheCounteractionofTrehaloseonUrea-InducedProteinDenaturationUsingMolecularDynamicsSimulation.TheJournalofPhysicalChemistryB,2012,116:7040-7047.SCI2区,Impactfactor:3.603 [16]F.-F.Liu,Z.Liu,S.Bai,X.-Y.Dong,andY.Sun*.Exploringtheinter-molecularinteractionsinamyloid-βprotofibrilwithmoleculardynamicssimulationsandmolecularmechanicsPoisson-Boltzmannsurfaceareafreeenergycalculations.TheJournalofChemicalPhysics,2012,Apr14;136(14):145101.SCI2区,Impactfactor:3.122 [17]S.-H.Wang,F.-F.,Liu,X.-Y.Dong,Y.Sun*.CalorimetricandSpectroscopicStudiesoftheInteractionsbetweenInsulinand(-)-Epigallocatechin-3-gallate.BiochemicalEngineeringJournal,2012,62:70-78.SCI2区,Impactfactor:2.467 [18]B.Huang,F.-F.Liu*,X.-Y.Dong,Y.Sun*.MolecularMechanismoftheEffectsofSaltandpHontheAffinitybetweenProteinAandHumanImmunoglobulinG1RevealedbyMolecularSimulations,TheJournalofPhysicalChemistryB,2012,116,424-433.SCI2区,Impactfactor:3.603 [19]Y.Sun*,Q.-H.Shi,L.Zhang,G.Zhao,F.-F.Liu:Adsorptionandchromatography.Ined.ComprehensiveBiotechnology,Vol.2,Chapter2.47.pp.665-679.Elsevier,2011. [20]F.-F.Liu,X.-Y.Dong,L.Z.He,A.P.J.Middelberg,Y.Sun*:MolecularInsightintoConformationalTransitionofAmyloidβ-Peptide42Inhibitedby(-)-Epigallocatechin-3-gallateProbedbyMolecularSimulations.TheJournalofPhysicalChemistryB,2011,115,11879-11887.SCI2区,Impactfactor:3.603 [21]B.Huang,F.-F.Liu,X.-Y.Dong,Y.Sun*.MolecularMechanismoftheAffinityInteractionsbetweenProteinAandHumanImmunoglobulinG1RevealedbyMolecularSimulations.TheJournalofPhysicalChemistryB,2011,115,4168-4176.SCI2区,Impactfactor:3.603 [22]S.-H.Wang,F.-F.,Liu,X.-Y.Dong,Y.Sun*.ThermodynamicAnalysisoftheMolecularInteractionsbetweenAmyloidβ-Peptide42and(-)-Epigallocatechin-3-gallate.TheJournalofPhysicalChemistryB,2010,114:11576-11583.SCI2区,Impactfactor:3.603 [23]F.-F.Liu,J.Luo,L.Zhang,X.-Y.Dong,Y.Sun*:Molecularbasisforpolyol-inducedproteinstabilityrevealedbymoleculardynamicssimulations.JournalofChemicalPhysics,2010,132:225103.SCI2区,Impactfactor:3.122 [24]F.-F.Liu,J.Luo,X.-Y.Dong,Y.Sun*:BIOT146-Moleculardynamicssimulationoftheinhibitioneffectoftrehaloseonthenucleationandelongationofamyloidbeta-peptideoligomers.AbstractsofpapersoftheAmericanChemicalSociety,Vol:238,146-BIOT,Aug162009.SCI检索 [25]F.-F.Liu,J.Luo,X.-Y.Dong,Y.Sun*:MolecularinsightintotheinhibitioneffectoftrehaloseonthenucleationandelongationofAmyloidβ-peptideoligomers.TheJournalofPhysicalChemistryB,2009,113(32):11320-11329.SCI2区,Impactfactor:3.603 [26]Y.Sun*,F.-F.Liu,Q.-H.Shi:Approachestohigh-performancepreparativechromatographyofproteins,AdvancesinBiochemicalEngineering/Biotechnology,2009,113:217-254.SCI2区,Impactfactor:2.600 [27]F.-F.Liu,X.-Y.Dong,Y.Sun*:Molecularmechanismfortheeffectsoftrehaloseonβ-hairpinfoldingrevealedbymoleculardynamicssimulation.JournalofMolecularGraphics&Modelling,2008,27(4):421-429.SCI3区,Impactfactor:2.177 [28]F.-F.Liu,X.-Y.Dong,Y.Sun*:Discoveryanddesignofaffinityligandsforproteinchromatography.JournalofBiotechnology,2008,136:497.SCI2区,Impactfactor:3.037 [29]F.-F.Liu,X.-Y.Dong,T.Wang,Y.Sun*:Rationaldesignofpeptideligandforaffinitychromatographyoftissue-typeplasminogenactivatorbythecombinationofdockingandmoleculardynamicssimulations.JournalofChromatographyA,2007,1175(2):249-258.SCI2区,Impactfactor:4.467 [30]F.-F.Liu,T.Wang,X.-Y.Dong,Y.Sun*:Rationaldesignofaffinitypeptideligandbyflexibledockingsimulation.JournalofChromatographyA,2007,1146(1):41–50.SCI2区,Impactfactor:4.467

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