Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases.
Cell Reports ( IF 7.5 ) Pub Date : 2018-09-25 , DOI: 10.1016/j.celrep.2018.08.090 Valentino Le Noci 1 , Simone Guglielmetti 2 , Stefania Arioli 2 , Chiara Camisaschi 3 , Francesca Bianchi 4 , Michele Sommariva 5 , Chiara Storti 5 , Tiziana Triulzi 1 , Chiara Castelli 3 , Andrea Balsari 4 , Elda Tagliabue 1 , Lucia Sfondrini 5
Cell Reports ( IF 7.5 ) Pub Date : 2018-09-25 , DOI: 10.1016/j.celrep.2018.08.090 Valentino Le Noci 1 , Simone Guglielmetti 2 , Stefania Arioli 2 , Chiara Camisaschi 3 , Francesca Bianchi 4 , Michele Sommariva 5 , Chiara Storti 5 , Tiziana Triulzi 1 , Chiara Castelli 3 , Andrea Balsari 4 , Elda Tagliabue 1 , Lucia Sfondrini 5
Affiliation
|
Pulmonary immunological tolerance to inhaled particulates might create a permissive milieu for lung metastasis. Lung microbiota contribute to pulmonary tolerance; here, we explored whether its manipulation via antibiotic or probiotic aerosolization favors immune response against melanoma metastasis. In lungs of vancomycin/neomycin-aerosolized mice, a decrease in bacterial load was associated with reduced regulatory T cells and enhanced T cell and NK cell activation that paralleled a significant reduction of melanoma B16 lung metastases. Reduction of metastases also occurred in lungs transplanted with bacterial isolates from antibiotic-treated lungs. Aerosolized Lactobacillus rhamnosus strongly promoted immunity against B16 lung metastases as well. Furthermore, probiotics or antibiotics improved chemotherapy activity against advanced B16 metastases. Thus, we identify a role for lung microbiota in metastasis and show that its targeting via aerosolization is a therapy that can prevent metastases and enhance responses to chemotherapy.
中文翻译：
抗生素或益生菌气雾疗法对肺微生物群的调节：促进针对肺转移的免疫监测的策略。
肺对吸入颗粒物的免疫耐受性可能会导致肺转移的环境恶化。肺微生物群有助于肺部耐受；在这里，我们探讨了其通过抗生素或益生菌雾化处理是否有利于抵抗黑色素瘤转移的免疫反应。在万古霉素/新霉素气雾化小鼠的肺中，细菌负荷的减少与调节性T细胞的减少以及增强的T细胞和NK细胞的激活相关，而这与黑素瘤B16肺转移的显着减少平行。从抗生素治疗过的肺中分离出细菌分离株的肺中，转移的减少也发生了。雾化鼠李糖乳杆菌也强烈增强了针对B16肺转移的免疫力。此外，益生菌或抗生素可改善针对晚期B16转移的化疗活性。
更新日期：2018-09-26
中文翻译：
抗生素或益生菌气雾疗法对肺微生物群的调节：促进针对肺转移的免疫监测的策略。
肺对吸入颗粒物的免疫耐受性可能会导致肺转移的环境恶化。肺微生物群有助于肺部耐受；在这里，我们探讨了其通过抗生素或益生菌雾化处理是否有利于抵抗黑色素瘤转移的免疫反应。在万古霉素/新霉素气雾化小鼠的肺中，细菌负荷的减少与调节性T细胞的减少以及增强的T细胞和NK细胞的激活相关，而这与黑素瘤B16肺转移的显着减少平行。从抗生素治疗过的肺中分离出细菌分离株的肺中，转移的减少也发生了。雾化鼠李糖乳杆菌也强烈增强了针对B16肺转移的免疫力。此外，益生菌或抗生素可改善针对晚期B16转移的化疗活性。
京公网安备 11010802027423号