Abstract Numerous efficient extraction methods have been developed for material recovery. However, most of these methods lack selectivity. Recently, we reported electromembrane extraction (EME) as a green, efficient and selective technology for simultaneous extraction and purification of trace targets for sample preparation purpose. Accordingly, EME could be a promising technique on resource conservation, for example, selective recovery of templates with high purity in molecular imprinting. In this work, we first investigated the potential of EME with different configurations for selective recovery of targets at high level (≥ 1000 μg mL−1). A semi-dynamic EME system was applied for EME of a basic template (propranolol) from molecularly imprinted samples prepared by precipitation polymerization and bulk polymerization, and the recoveries were 61% and 55%, respectively. The selectivity of EME for template recovery from real samples was confirmed by UV–vis, HPLC-UV and MS measurements. Moreover, the universality of EME for template recovery was verified by efficient extraction of an acidic template (probenecid). Definitely, EME could be used to solve the historic issue of template recovery in molecular imprinting, and shows great potential for selective extraction of ionizable compounds from complex samples in a single step.

中文翻译：

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高含量物质的电膜萃取：分子印迹中模板选择性回收的新方法

摘要 已经开发了许多用于材料回收的有效提取方法。然而，这些方法中的大多数缺乏选择性。最近，我们报道了电膜提取 (EME) 作为一种绿色、高效和选择性的技术，用于同时提取和纯化痕量目标以进行样品制备。因此，EME 可能是一种很有前途的资源保护技术，例如，分子印迹中高纯度模板的选择性回收。在这项工作中，我们首先研究了具有不同配置的 EME 在高水平（≥ 1000 μg mL-1）选择性回收目标方面的潜力。将半动态 EME 系统应用于基本模板（心得安）的 EME，该模板来自通过沉淀聚合和本体聚合制备的分子印迹样品，回收率分别为 61% 和 55%。通过 UV-vis、HPLC-UV 和 MS 测量证实了 EME 对从实际样品中回收模板的选择性。此外，通过有效提取酸性模板（丙磺舒）验证了 EME 对模板回收的普遍性。毫无疑问，EME可用于解决分子印迹中模板回收的历史问题，并显示出通过一步从复杂样品中选择性提取可电离化合物的巨大潜力。