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Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination
ACS Nano ( IF 15.8 ) Pub Date : 2018-05-17 00:00:00 , DOI: 10.1021/acsnano.7b09041 Rong Yang 1 , Jun Xu 1 , Ligeng Xu 1 , Xiaoqi Sun 1 , Qian Chen 1 , Yuhuan Zhao 1 , Rui Peng 1 , Zhuang Liu 1
ACS Nano ( IF 15.8 ) Pub Date : 2018-05-17 00:00:00 , DOI: 10.1021/acsnano.7b09041 Rong Yang 1 , Jun Xu 1 , Ligeng Xu 1 , Xiaoqi Sun 1 , Qian Chen 1 , Yuhuan Zhao 1 , Rui Peng 1 , Zhuang Liu 1
Affiliation
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Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we present a strategy to construct cancer vaccines by encapsulating immune-adjuvant nanoparticles with cancer cell membranes modified by mannose. Poly(d,l-lactide-co-glycolide) nanoparticles are first loaded with toll-like receptor 7 agonist, imiquimod (R837). Those adjuvant nanoparticles (NP-R) are then coated with cancer cell membranes ([email protected]), whose surface proteins could act as tumor-specific antigens. With further modification with mannose moiety ([email protected]), the obtained nanovaccine shows enhanced uptake by antigen presenting cells such as dendritic cells, which would then be stimulated to the maturation status to trigger antitumor immune responses. With great efficacy to delay tumor development as a prevention vaccine, vaccination with such [email protected] in combination with checkpoint-blockade therapy further demonstrates outstanding therapeutic efficacy to treat established tumors. Therefore, our work presents an innovative way to fabricate cancer nanovaccines, which in principle may be applied for a wide range of tumor types.
中文翻译：
甘露糖修饰的癌细胞膜涂层佐剂纳米颗粒用于有效的抗癌疫苗接种
近年来，用于癌症预防和治疗的肿瘤疫苗在癌症免疫治疗领域引起了极大的兴趣。在这项工作中，我们提出了一种通过用甘露糖修饰的癌细胞膜封装免疫佐剂纳米颗粒来构建癌症疫苗的策略。聚（d，升-lactide-共-乙交酯）纳米颗粒首先负载有Toll样受体7激动剂咪喹莫特（R837）。然后，将那些佐剂纳米颗粒（NP-R）涂上癌细胞膜（[电子邮件保护]），其表面蛋白可作为肿瘤特异性抗原。随着甘露糖部分的进一步修饰（[电子邮件保护]），获得的纳米疫苗显示出抗原呈递细胞（如树突状细胞）的摄取增强，然后将其刺激至成熟状态以触发抗肿瘤免疫反应。作为预防疫苗具有延缓肿瘤发展的巨大功效，用这种[受电子邮件保护]的疫苗与检查点封锁疗法相结合的疫苗进一步证明了出色的治疗功效，可用于治疗已建立的肿瘤。因此，我们的工作提出了一种创新的方法来制备癌症纳米疫苗，
更新日期：2018-05-17
中文翻译：
甘露糖修饰的癌细胞膜涂层佐剂纳米颗粒用于有效的抗癌疫苗接种
近年来，用于癌症预防和治疗的肿瘤疫苗在癌症免疫治疗领域引起了极大的兴趣。在这项工作中，我们提出了一种通过用甘露糖修饰的癌细胞膜封装免疫佐剂纳米颗粒来构建癌症疫苗的策略。聚（d，升-lactide-共-乙交酯）纳米颗粒首先负载有Toll样受体7激动剂咪喹莫特（R837）。然后，将那些佐剂纳米颗粒（NP-R）涂上癌细胞膜（[电子邮件保护]），其表面蛋白可作为肿瘤特异性抗原。随着甘露糖部分的进一步修饰（[电子邮件保护]），获得的纳米疫苗显示出抗原呈递细胞（如树突状细胞）的摄取增强，然后将其刺激至成熟状态以触发抗肿瘤免疫反应。作为预防疫苗具有延缓肿瘤发展的巨大功效，用这种[受电子邮件保护]的疫苗与检查点封锁疗法相结合的疫苗进一步证明了出色的治疗功效，可用于治疗已建立的肿瘤。因此，我们的工作提出了一种创新的方法来制备癌症纳米疫苗，
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