Metal–organic frameworks (MOFs) are attracting considerable attention as a result of their unique structural properties, such as a high surface area, highly porous topology, and tunable size and shape, which enable them to have potential applications as a new class of carriers for functional agent or drug delivery. However, most of the MOFs and the polymers used are not pharmaceutically acceptable. For the first time, this study successfully conducted the rapid synthesis of cyclodextrin metal–organic frameworks (CD-MOFs) through a facile and green seed-mediated method. The size control, crystal structure, and thermal properties of CD-MOFs with and without seeds were investigated. When 1 mg/mL seed was added, the size of γ-CD-MOF crystals decreased from 6.2 ± 0.8 to 1.8 ± 0.4 μm. The CD-MOFs synthesized though the seed-mediated method had higher crystallinity and thermal stability than those that were not. Furthermore, the CD-MOFs could encapsulate hydrophobic molecules, such as Nile red (NR), which was chosen as a model, and the interaction mechanism between γ-CD-MOFs and NR was investigated. Results showed the formation of a 1:1 complex between NR and CD-MOFs, demonstrating the potential of these polymers as carriers for hydrophobic drug delivery applications.

中文翻译：

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种子介导的疏水性分子包封法绿色合成环糊精基金属有机骨架

金属有机框架（MOF）由于其独特的结构特性（例如高表面积，高度多孔的拓扑结构以及可调整的大小和形状）而受到了广泛的关注，这使其有可能作为新型载具应用用于功能剂或药物递送。但是，大多数MOF和所用的聚合物都不是药学上可接受的。这项研究首次通过一种简便且绿色的种子介导方法成功进行了环糊精金属有机骨架（CD-MOF）的快速合成。研究了有和没有种子的CD-MOF的尺寸控制，晶体结构和热性能。当添加1 mg / mL种子时，γ-CD-MOF晶体的尺寸从6.2±0.8减小至1.8±0.4μm。通过种子介导的方法合成的CD-MOF的结晶度和热稳定性高于没有种子的方法。此外，CD-MOFs可以包裹疏水分子，如尼罗红（NR），被选为模型，并研究了γ-CD-MOFs与NR之间的相互作用机理。结果表明，NR和CD-MOF之间形成了1：1的络合物，证明了这些聚合物作为疏水性药物递送应用载体的潜力。