White adipose tissue (WAT) stores excess energy as triglycerides, and brown adipose tissue (BAT) is specialized in dissipating energy as heat. The endocannabinoid system (ECS) is involved in a broad range of physiological processes and is increasingly recognized as a key player in adipose tissue metabolism. High ECS tonus in the fed state is associated with a disadvantageous metabolic phenotype, and this has led to a search for pharmacological strategies to inhibit the ECS. In this review we present recent developments that cast light on the regulation of adipose tissue metabolism by the ECS, and we discuss novel treatment options including the modulation of endocannabinoid synthesis and breakdown enzymes.

中文翻译：

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内源性大麻素系统对脂肪组织代谢的调节

白色脂肪组织 (WAT) 以甘油三酯的形式储存多余的能量，而棕色脂肪组织 (BAT) 则专门以热量的形式散发能量。内源性大麻素系统 (ECS) 涉及广泛的生理过程，并且越来越多地被认为是脂肪组织代谢的关键参与者。进食状态下的高 ECS 紧张与不利的代谢表型相关，这导致寻找抑制 ECS 的药理学策略。在这篇综述中，我们介绍了最近的发展，揭示了 ECS 对脂肪组织代谢的调节，并讨论了新的治疗方案，包括调节内源性大麻素合成和分解酶。