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Indocyanine Green-holo-Transferrin Nanoassemblies for Tumor-Targeted Dual-Modal Imaging and Photothermal Therapy of Glioma
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1021/acsami.7b14076 Mingting Zhu 1, 2 , Zonghai Sheng 2 , Yali Jia 1, 2 , Dehong Hu 2 , Xin Liu 2 , Xianyuan Xia 3 , Chengbo Liu 3 , Pan Wang 1 , Xiaobing Wang 1, 2 , Hairong Zheng 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1021/acsami.7b14076 Mingting Zhu 1, 2 , Zonghai Sheng 2 , Yali Jia 1, 2 , Dehong Hu 2 , Xin Liu 2 , Xianyuan Xia 3 , Chengbo Liu 3 , Pan Wang 1 , Xiaobing Wang 1, 2 , Hairong Zheng 2
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Active-targeted cancer imaging and therapy of glioma has attracted much attention in theranostic nanomedicine. As a promising tumor-targeting ligand, holo-transferrin (holo-Tf) has been applied for enhancing delivery of nanotheranostics. However, holo-Tf-based nanoassemblies for active targeting mediated multimodal imaging and therapeutics have not been previously reported. Here, we develop a one-step method for the preparation of holo-Tf-indocyanine green (holo-Tf-ICG) nanoassemblies for fluorescence (FL) and photoacoustic (PA) dual-modal imaging and photothermal therapy (PTT) of glioma. The nanoassemblies are formed by hydrophobic interaction and hydrogen bonds between holo-Tf and ICG, which exhibit excellent active tumor-targeting and high biocompability. The brain tumor with highly expressed Tf receptor can be clearly observed with holo-Tf-ICG nanoassemblies base on FL and PA dual-modal imaging in subcutaneous and orthotopic glioma models. Under the near-infrared laser irradiation, the holo-Tf-ICG nanoassemblies accumulated in tumor regions can efficiently convert laser energy into hyperthermia for tumor ablation. The novel theranostic nanoplatform holds great promise for precision diagnosis and treatment of glioma.
中文翻译：
吲哚菁绿-全运铁蛋白纳米组件的肿瘤靶向双模态成像和胶质瘤的光热疗法。
胶质瘤的主动靶向癌症成像和治疗已在治疗诊断纳米医学中引起了广泛关注。作为有希望的靶向肿瘤的配体，全运铁蛋白（holo-Tf）已被用于增强纳米热力学的传递。然而，以前尚未报道过用于主动靶向介导的多模态成像和治疗的基于全Tf的纳米组件。在这里，我们开发了一步法制备胶质瘤的荧光（FL）和光声（PA）双模态成像和光热疗法（PTT）的整体Tf-吲哚菁绿（holo-Tf-ICG）纳米组件。纳米组件是由疏水性相互作用和全息图Tf与ICG之间的氢键形成的，它们具有出色的靶向肿瘤活性和高生物相容性。在皮下和原位神经胶质瘤模型中，基于FL和PA双模态成像的holo-Tf-ICG纳米组件可以清楚地观察到具有高表达Tf受体的脑肿瘤。在近红外激光照射下，聚集在肿瘤区域中的完整Tf-ICG纳米组件可以有效地将激光能量转换成高热，从而消融肿瘤。新型的治疗性纳米平台在神经胶质瘤的精确诊断和治疗方面具有广阔的前景。
更新日期：2017-10-31
中文翻译：
吲哚菁绿-全运铁蛋白纳米组件的肿瘤靶向双模态成像和胶质瘤的光热疗法。
胶质瘤的主动靶向癌症成像和治疗已在治疗诊断纳米医学中引起了广泛关注。作为有希望的靶向肿瘤的配体，全运铁蛋白（holo-Tf）已被用于增强纳米热力学的传递。然而，以前尚未报道过用于主动靶向介导的多模态成像和治疗的基于全Tf的纳米组件。在这里，我们开发了一步法制备胶质瘤的荧光（FL）和光声（PA）双模态成像和光热疗法（PTT）的整体Tf-吲哚菁绿（holo-Tf-ICG）纳米组件。纳米组件是由疏水性相互作用和全息图Tf与ICG之间的氢键形成的，它们具有出色的靶向肿瘤活性和高生物相容性。在皮下和原位神经胶质瘤模型中，基于FL和PA双模态成像的holo-Tf-ICG纳米组件可以清楚地观察到具有高表达Tf受体的脑肿瘤。在近红外激光照射下，聚集在肿瘤区域中的完整Tf-ICG纳米组件可以有效地将激光能量转换成高热，从而消融肿瘤。新型的治疗性纳米平台在神经胶质瘤的精确诊断和治疗方面具有广阔的前景。
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