glomerular disease are unknown. Methods: We performed a cross-sectional and longitudinal analysis of participants in the Cure Glomerulonephropathy (CureGN) cohort. Preterm (<37 weeks’ gestation) was compared to term (≥37 weeks’ gestation). A survival analysis and adjusted Cox proportional hazards model were used to examine a composite outcome of 40% decline in estimated glomerular filtration rate (eGFR) or progression to kidney failure. An adjusted logistic regression model was used to examine remission of proteinuria. Results: There were 2,205 term and 235 preterm participants. APOL1 risk alleles were more common in those born preterm. More pediatric than adult participants in CureGN were born preterm: 12.8% vs. 7.69% (P<0.001). Adults born preterm as compared to term had a higher prevalence of Focal Segmental Glomerulosclerosis (FSGS) (35% vs. 25%, P=0.01) and APOL1 high-risk genotype (9.4% vs 4.2%, P=0.01). Participants born preterm had a shorter time interval to a 40% eGFR decline/kidney failure after biopsy (P=0.001). In adjusted analysis, preterm participants were 28% more likely to develop 40% eGFR decline/kidney failure (Hazard Ratio: 1.28 [1.07, 1.54], P=0.008) and 38% less likely to attain complete remission of proteinuria (Odds Ratio: 0.62 [0.45, 0.87], P=0.006). There was no significant difference in cardiovascular events. Conclusions: Preterm birth was a risk factor for adverse outcomes in this heterogenous cohort of children and adults with glomerular disease. Adults born preterm were more likely to have an APOL1 high-risk genotype and FSGS. In analyses adjusted for FSGS and APOL1 risk status, there was less remission and faster progression of kidney disease in those born preterm. Copyright © 2024 by the American Society of Nephrology...

中文翻译：

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早产与儿童和成人肾小球疾病不良后果的关系

肾小球疾病尚不清楚。方法：我们对治愈肾小球肾病 (CureGN) 队列的参与者进行了横断面和纵向分析。将早产（<37 周妊娠）与足月（≥37 周妊娠）进行比较。使用生存分析和调整后的 Cox 比例风险模型来检查估计肾小球滤过率 (eGFR) 下降 40% 或进展为肾衰竭的复合结果。使用调整后的逻辑回归模型来检查蛋白尿的缓解情况。结果：共有 2,205 名足月参与者和 235 名早产参与者。 APOL1 风险等位基因在早产儿中更为常见。 CureGN 中的儿童早产率高于成人：12.8% vs. 7.69%（P<0.001）。与足月出生的成年人相比，早产儿的局灶节段性肾小球硬化症（FSGS）（35% vs. 25%，P=0.01）和 APOL1 高危基因型（9.4% vs 4.2%，P=0.01）的患病率更高。早产参与者在活检后 eGFR 下降 40%/肾衰竭的时间间隔较短 (P=0.001)。在调整分析中，早产参与者出现 40% eGFR 下降/肾衰竭的可能性高出 28%（风险比：1.28 [1.07, 1.54]，P=0.008），而蛋白尿完全缓解的可能性低 38%（优势比： 0.62 [0.45, 0.87], P=0.006)。心血管事件没有显着差异。结论：早产是肾小球疾病儿童和成人异质队列中不良结局的危险因素。早产成年人更有可能具有 APOL1 高危基因型和 FSGS。在针对 FSGS 和 APOL1 风险状态进行调整的分析中，早产儿的肾脏疾病缓解较少且进展较快。版权所有 © 2024 美国肾脏病学会...