Background The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, adiposity may differentially influence these strength criteria and produce discrepant sarcopenia prevalence. Objective To determine the prevalence of sarcopenia using HGS or the CST, and to investigate the associations between these strength criteria and adiposity in adults with type 2 diabetes mellitus. Methods The EWGSOP2 definition was used to assess the prevalence of probable (low muscle strength), confirmed (plus low muscle mass) and severe (plus poor physical performance) sarcopenia. Linear regression models were used to study the association between different measures of muscle strength and adiposity. Results We used data from 732 adults with type 2 diabetes mellitus (35.7% female, aged 64 ± 8 years, body mass index 30.7 ± 5.0 kg/m2). Using the CST compared with HGS produced a higher prevalence of probable (31.7% vs. 7.1%), confirmed (5.6% vs. 1.6%) and severe (1.0% vs. 0.3%) sarcopenia, with poor agreement between strength criteria to identify probable sarcopenia. CST performance, but not HGS, was significantly associated with all measures of adiposity in unadjusted and adjusted models. Conclusions Higher levels of adiposity may impact CST performance, but not HGS, resulting in a higher prevalence of sarcopenia in adults with type 2 diabetes mellitus. Consideration should be paid to the most appropriate measure of muscle function in this population.

中文翻译：

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根据 2 型糖尿病成人的握力或椅子站立表现来评估肌少症患病率

背景 更新后的欧洲老年人肌少症工作组 (EWGSOP2) 建议握力 (HGS) 和椅立测试 (CST) 来评估肌肉力量，其中 CST 是下肢力量的便捷代表。然而，肥胖可能会对这些力量标准产生不同的影响，并产生不同的肌肉减少症患病率。目的 使用 HGS 或 CST 确定肌肉减少症的患病率，并研究这些力量标准与成人 2 型糖尿病患者肥胖之间的关联。方法 EWGSOP2 定义用于评估可能（低肌肉力量）、确诊（加上低肌肉质量）和严重（加上身体机能差）少肌症的患病率。线性回归模型用于研究不同的肌肉力量测量与肥胖之间的关联。结果 我们使用了 732 名 2 型糖尿病成人患者的数据（35.7% 为女性，年龄 64 ± 8 岁，体重指数 30.7 ± 5.0 kg/m2）。与 HGS 相比，使用 CST 产生的疑似肌少症（31.7% vs. 7.1%）、确诊肌少症（5.6% vs. 1.6%）和严重肌少症（1.0% vs. 0.3%）的患病率较高，并且用于识别肌少症的力量标准之间的一致性较差可能是肌肉减少症。在未调整和调整模型中，CST 表现（而非 HGS）与所有肥胖指标显着相关。结论 较高的肥胖水平可能会影响 CST 表现，但不会影响 HGS，从而导致 2 型糖尿病成人患者肌肉减少症的患病率较高。应考虑对该人群的肌肉功能进行最合适的测量。