Heavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial products. Recent research strongly suggests a connection between cardiovascular disease and exposure to toxic heavy metals. Epidemiological, basic, and clinical studies have revealed that heavy metals can promote the production of reactive oxygen species, which can then exacerbate reactive oxygen species generation and induce inflammation, resulting in endothelial dysfunction, lipid metabolism distribution, disruption of ion homeostasis, and epigenetic changes. Over time, heavy metal exposure eventually results in an increased risk of hypertension, arrhythmia, and atherosclerosis. Strengthening public health prevention and the application of chelation or antioxidants, such as vitamins and beta-carotene, along with minerals, such as selenium and zinc, can diminish the burden of cardiovascular disease attributable to metal exposure.

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重金属暴露与心血管疾病

重金属是有害的环境污染物，因其对人类心血管疾病的健康危害而受到广泛关注。重金属，包括铅、镉、汞、砷和铬，存在于空气、水、土壤、食品和工业产品等多种来源中。最近的研究强烈表明心血管疾病与接触有毒重金属之间存在联系。流行病学、基础和临床研究表明，重金属可以促进活性氧的产生，从而加剧活性氧的产生并诱发炎症，导致内皮功能障碍、脂质代谢分布、离子稳态破坏和表观遗传变化。随着时间的推移，重金属暴露最终会导致高血压、心律失常和动脉粥样硬化的风险增加。加强公共卫生预防和应用螯合剂或抗氧化剂（例如维生素和β-胡萝卜素）以及矿物质（例如硒和锌）可以减轻因金属接触而导致的心血管疾病的负担。