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A glimpse into Giardia lamblia unique translational machinery
Structure ( IF 5.7 ) Pub Date : 2024-04-04 , DOI: 10.1016/j.str.2024.03.001
Jailson Brito Querido

Eiler et al. used cryo-electron microscopy to determine a 2.49 Å resolution structure of Giardia lamblia 80S ribosome bound to tRNA, mRNA, and the anti-protozoal drug emetine. The structure reveals some critical aspects of translation in G. lamblia, including the lack of ribosomal protein RACK1, and how emetine blocks translation by interacting with both the ribosome and mRNA.



中文翻译:

一睹贾第鞭毛虫独特的转化机制

艾勒等人。使用冷冻电子显微镜确定了与 tRNA、mRNA 和抗原虫药物依米丁结合的贾第鞭毛虫80S 核糖体的 2.49 Å 分辨率结构。该结构揭示了G.lambdalia翻译的一些关键方面,包括核糖体蛋白 RACK1 的缺乏,以及依米丁如何通过与核糖体和 mRNA 相互作用来阻断翻译。

更新日期:2024-04-04
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