To evaluate the diagnostic value of QuantiFERON Gold (QFT-G) testing for ocular inflammation in a low prevalence tuberculosis (TB) area. Diagnostic utility analysis. A review was performed for all uveitis patients who underwent QFT-G testing at the University of Colorado Eye Center from 2009 to 2022. Records were reviewed to assess QFT-G positivity rate and to identify which patients were tested for diagnostic purposes, defined as meeting the Standardization of Uveitis Nomenclature (SUN) criteria for tubercular uveitis (TBU): anterior uveitis with iris nodules, serpiginous-like choroiditis, choroidal nodule resembling a tuberculoma, multifocal choroiditis, or occlusive retinal vasculitis. A total of 388 patients with uveitis underwent QFT-G testing, of which 17 (4.38%) were positive. Only one (5.88%) patient had true TBU with anterior uveitis with iris nodules. The remaining 16 (94.1%) patients did not meet SUN criteria for TBU and were incidentally found to be QFT-G positive during laboratory work-up prior to immunosuppression. The positive predictive value was 100% when QFT-G testing was performed in patients who met SUN criteria for TBU, whereas the positive predictive value was 0% for QFT-G testing performed in patients who did not meet SUN criteria for TBU. In low prevalence areas, the majority of QFT-G positive tests in uveitis patients are coincidental and unrelated to their uveitic disease process. The diagnostic value of a TB test is likely to be minimal unless the SUN clinical criteria for tubercular uveitis are met.

中文翻译：

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QuantiFERON-Gold 检测对结核病低流行地区眼部炎症患者的诊断效用

评估 QuantiFERON Gold (QFT-G) 检测在结核病 (TB) 低流行地区对眼部炎症的诊断价值。诊断效用分析。对 2009 年至 2022 年在科罗拉多大学眼科中心接受 QFT-G 测试的所有葡萄膜炎患者进行了审查。审查记录以评估 QFT-G 阳性率并确定哪些患者接受了诊断目的测试，定义为满足葡萄膜炎命名法标准化 (SUN) 结核性葡萄膜炎 (TBU) 的标准：伴有虹膜结节的前葡萄膜炎、匐行状脉络膜炎、类似结核瘤的脉络膜结节、多灶性脉络膜炎或闭塞性视网膜血管炎。共有388例葡萄膜炎患者接受了QFT-G检测，其中17例（4.38%）呈阳性。只有 1 名患者 (5.88%) 患有真正的 TBU，伴有前葡萄膜炎并伴有虹膜结节。其余 16 名 (94.1%) 患者不符合 TBU 的 SUN 标准，并在免疫抑制前的实验室检查中偶然发现 QFT-G 阳性。当对符合 SUN TBU 标准的患者进行 QFT-G 测试时，阳性预测值为 100%，而对不符合 SUN TBU 标准的患者进行 QFT-G 测试，阳性预测值为 0%。在低流行地区，葡萄膜炎患者中大多数 QFT-G 阳性检测是巧合的，与其葡萄膜炎疾病过程无关。除非符合结核性葡萄膜炎的 SUN 临床标准，否则结核病检测的诊断价值可能很小。