This study reports the copper‐catalyzed α‐indolmethylation of 2‐pyridylacetates with 3‐indoleacetic acids. This reaction offers a approach to generating alkylideneindolenine electrophiles via the oxidative decarboxylation of 3‐indoleacetic acids. The developed reaction system demonstrates good versatility, extending beyond the indolmethylation of 2‐ pyridylacetates to include activated esters and nitroalkanes. Moreover, a biological evaluation revealed that several products exhibited antiproliferative activity against different cancer cell lines.

中文翻译：

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铜催化 2-吡啶乙酸酯与 3-吲哚乙酸通过亚烷基吲哚中间体发生 α-吲哚甲基化


本研究报告了铜催化 2-吡啶乙酸酯与 3-吲哚乙酸的 α-吲哚甲基化反应。该反应提供了一种通过 3-吲哚乙酸的氧化脱羧生成亚烷基吲哚亲电子试剂的方法。所开发的反应系统表现出良好的多功能性，不仅限于2-吡啶基乙酸酯的吲哚甲基化，还包括活化酯和硝基烷烃。此外，生物学评估表明，几种产品对不同的癌细胞系表现出抗增殖活性。