Chemical approaches, such as those that leverage induced proximity, targeted degradation, synthetic gene regulators or protein design offer opportunities to therapeutically target cellular processes that have long been thought of as undruggable. We report on the progress and the potential for transformative collaborations between fields discussed at the 2023 Bringing Chemistry to Medicine symposium at St. Jude Children’s Research Hospital.

中文翻译：

---

将化学引入医学，重新定义不可成药的药物

化学方法，例如利用诱导接近、靶向降解、合成基因调节剂或蛋白质设计的化学方法，为治疗长期以来被认为不可成药的细胞过程提供了机会。我们报告了在圣裘德儿童研究医院举行的 2023 年将化学引入医学研讨会上讨论的各领域变革性合作的进展和潜力。