The impact of circadian rhythms on cardiovascular function and disease development is well established, with numerous studies in genetically modified animals emphasizing the circadian molecular clock’s significance in the pathogenesis and pathophysiology of myocardial ischemia and heart failure progression. However, translational preclinical studies targeting the heart's circadian biology are just now emerging and are leading to the development of a novel field of medicine termed circadian medicine. In this review, we explore circadian molecular mechanisms and novel therapies, including (1) intense light, (2) small molecules modulating the circadian mechanism, and (3) chronotherapies such as cardiovascular drugs and meal timings. These promise significant clinical translation in circadian medicine for cardiovascular disease. (4) Additionally, we address the differential functioning of the circadian mechanism in males versus females, emphasizing the consideration of biological sex, gender, and aging in circadian therapies for cardiovascular disease.

中文翻译：

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昼夜节律对心肌缺血再灌注损伤和心力衰竭的影响

昼夜节律对心血管功能和疾病发展的影响已得到充分证实，大量针对转基因动物的研究强调了昼夜节律分子钟在心肌缺血和心力衰竭进展的发病机制和病理生理学中的重要性。然而，针对心脏昼夜节律生物学的转化临床前研究刚刚兴起，并导致了称为昼夜节律医学的新医学领域的发展。在这篇综述中，我们探索了昼夜节律分子机制和新疗法，包括（1）强光，（2）调节昼夜节律机制的小分子，以及（3）时间疗法，例如心血管药物和进餐时间。这些有望在心血管疾病的昼夜节律医学中产生重大的临床转化。(4) 此外，我们还讨论了男性与女性昼夜节律机制的差异功能，强调在心血管疾病的昼夜节律治疗中考虑生物性别、性别和衰老。