Protein structure determination and prediction, active site detection, and protein sequence alignment techniques all exploit information about protein structure and structural relationships. For membrane proteins, however, there is limited agreement among available online tools for highlighting and mapping such structural similarities. Moreover, no available resource provides a systematic overview of quaternary and internal symmetries, and their orientation relative to the membrane, despite the fact that these properties can provide key insights into membrane protein function and evolution. Here, we describe the Encyclopedia of Membrane Proteins Analyzed by Structure and Symmetry (EncoMPASS), a database for relating integral membrane proteins of known structure from the points of view of sequence, structure, and symmetry. EncoMPASS is accessible through a web interface, and its contents can be easily downloaded. This allows the user not only to focus on specific proteins, but also to study general properties of the structure and evolution of membrane proteins.

中文翻译：

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EncoMPASS：通过结构和对称性分析的膜蛋白百科全书


蛋白质结构测定和预测、活性位点检测和蛋白质序列比对技术都利用有关蛋白质结构和结构关系的信息。然而，对于膜蛋白，用于突出和绘制此类结构相似性的在线工具之间的一致性有限。此外，没有可用的资源提供四元对称性和内部对称性及其相对于膜的方向的系统概述，尽管这些特性可以提供对膜蛋白功能和进化的关键见解。在这里，我们描述了结构和对称性分析膜蛋白百科全书（EncoMPASS），这是一个从序列、结构和对称性角度关联已知结构的完整膜蛋白的数据库。 EncoMPASS 可通过网络界面访问，并且可以轻松下载其内容。这使得用户不仅可以关注特定蛋白质，还可以研究膜蛋白结构和进化的一般特性。