BackgroundThis study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non‐surgical mechanical debridement (MD) on clinical parameters and peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri‐implantitis.MethodsA total of 49 patients who underwent non‐surgical treatment of peri‐implantitis were randomly divided into two groups. The control group (n = 26) received MD alone, while the laser group (n = 23) received MD+Er,Cr:YSGG. The clinical parameters (bleeding on probing [BoP], gingival index [GI], plaque index [PI], probing depth [PD]), marginal bone loss (MBL), and biochemical parameters (RANKL and OPG) were measured at baseline (T0) and 6 months after treatment (T1).ResultsThere was a statistically significant decrease in all the clinical parameters in both groups at T1 compared to T0 (p < 0.05). The BoP, PD, MBL, and RANKL reductions were significantly higher in the laser group than in the control group (p = 0.046, p = 0.014, p = 0.047, p = 0.045, respectively). The OPG levels significantly increased at T1 in the laser group (p = 0.01). The OPG/RANKL ratio increased significantly in both groups at T1, which favored the laser group (p = 0.034).ConclusionsAlthough both treatment methods were influential in treating peri‐implantitis, the laser group (MD+Er,Cr:YSGG) yielded more favorable results by reducing clinical inflammation and improving biochemical parameters. Based on these findings, Er,Cr:YSGG laser may be a beneficial adjunctive treatment in this patient group.

中文翻译：

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Er,Cr:YSGG激光应用对种植体周围炎非手术治疗中种植体周围沟液受体核因子κB配体激活剂和骨保护素水平的影响评估：一项随机临床试验

背景本研究旨在探讨铒、铬掺杂：钇、钪、镓、石榴石（Er,Cr:YSGG）激光应用结合非手术机械清创（MD）对临床参数和种植体周围裂隙液受体激活剂的影响核因子κB配体（RANKL）和骨保护素（OPG）水平在种植体周围炎治疗中的影响。方法将49例接受非手术治疗的种植体周围炎患者随机分为两组。对照组（n= 26) 单独接受 MD，而激光组 (n= 23) 收到 MD+Er,Cr:YSGG。在基线时测量临床参数（探诊出血 [BoP]、牙龈指数 [GI]、菌斑指数 [PI]、探诊深度 [PD]）、边缘骨丢失 (MBL) 和生化参数（RANKL 和 OPG）。 T0)和治疗后6个月(T1)。结果T1时两组各项临床参数较T0均有统计学意义的下降(p< 0.05）。激光组的 BoP、PD、MBL 和 RANKL 降低显着高于对照组（p= 0.046,p= 0.014,p= 0.047,p= 0.045，分别）。激光组的 OPG 水平在 T1 时显着增加（p= 0.01）。两组在 T1 时的 OPG/RANKL 比值均显着增加，这有利于激光组（p= 0.034）。结论虽然两种治疗方法对治疗种植体周围炎都有影响，但激光组（MD+Er，Cr：YSGG）通过减少临床炎症和改善生化参数产生了更有利的结果。基于这些发现，Er,Cr:YSGG 激光可能是该患者群体的有益辅助治疗。