Background Frailty in older people can seriously affect their quality of life and increase the demand for long-term care and health care expenses. Aims of this study are to provide an evidence-based basis for clinical practice of frailty in older people by systematically searching for the best current evidence on interventions for the prevention and management of frailty. Methods According to the ‘6S’ evidence resource model, evidence retrieval is searched from the top-down and collected relevant guidelines, best practices, evidence summaries, systematic reviews and expert consensus. The retrieval time limit was from the database establishment to 20 March 2023. Two reviewers independently screened and evaluated the literature, and then extracted and summarised the evidence according to the JBI grading of evidence and recommendation system. Results A total of 44 publications were finally included, including 12 guidelines, 5 best practices, 4 expert consensus, 5 evidence summaries and 18 systematic reviews. Through the induction and integration of the evidence, the evidence was finally summarised from eight aspects: frailty screening, frailty assessment, exercise intervention, nutrition intervention, multi-domain intervention, drug administration, social support and health education, and 43 best evidences were formed. Conclusions This study summarised the best evidence for the prevention and management of frailty from eight aspects, which can provide guidance for clinical or community medical staff to develop and apply frailty intervention and practice programmes for older people and improved the clinical outcome and quality of life of older people.

中文翻译：

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预防和管理衰弱的最佳证据总结

背景 老年人的衰弱会严重影响他们的生活质量，并增加对长期护理和医疗保健费用的需求。本研究的目的是通过系统地寻找预防和管理衰弱干预措施的最佳当前证据，为老年人衰弱的临床实践提供循证基础。方法按照“6S”证据资源模型，自上而下检索证据，收集相关指南、最佳实践、证据总结、系统评价和专家共识。检索时限为建库至2023年3月20日。两名评审员独立对文献进行筛选和评价，然后根据JBI证据分级和推荐系统提取和总结证据。结果 最终纳入44篇出版物，其中包括12篇指南、5篇最佳实践、4篇专家共识、5篇证据总结和18篇系统评价。通过证据的归纳和整合，最终从衰弱筛查、衰弱评估、运动干预、营养干预、多领域干预、药物管理、社会支持和健康教育八个方面总结证据，形成43个最佳证据。结论 本研究从八个方面总结了衰弱预防和管理的最佳证据，可为临床或社区医务人员制定和应用老年人衰弱干预和实践方案提供指导，提高老年人的临床结局和生活质量。老年人。