Introduction The burden of PD has exponentially risen from 2.5 million in 1990, to 6.1 million in 2016 (PD Collaborators. Lancet Neurol. 2018; 17(11):939-53). This is due to ageing population, increased longevity, increased duration of the disease and improved diagnosis. The aim of our study was to identify the trend on deaths related to PD and Parkinsonism over the last decade. Methods We collected our data from the Office of the National Statistics, using codes G20 (PD), G21 (Secondary Parkinsonism) and G22 (Parkinsonism classified elsewhere), to extract the number of deaths coded under these conditions from 2013 to 2021. The data was only available for England and Wales. Results Total number of deaths including all codes from 2013 to 2021 were 4518, 4950, 5542, 5734, 5936, 6508, 6207, 7414 and 7117. Deaths coded under G.20 are far higher compared to deaths coded under the others. Conclusion The number of deaths related to PD has been gradually increasing and has nearly doubled over the last 9 years. Although Covid 19 may have contributed to this increase over the last two years, there is an overall rising trend. We think this is primarily due to people with PD living longer leading to an increased prevalence and duration of the condition. This is linked to sarcopenia, frailty, immobility, cognitive impairment and dysphagia contributing to increased mortality in later years. Another reason could be due to more accurate documentation in death certificates. Even though there has been concerns that deaths certificates have not been accurately coded to include PD, (Hobson, Meara. 2018; 8(2):e018969), there is probably an improvement after the introduction of Medical Examiner services. It is important to recognise the increasing burden of PD to enable us to plan and invest in resources to improve the care of these patients.

中文翻译：

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1851 与帕金森病 (PD) 和帕金森病相关的死亡人数不断增加

简介 PD 的负担从 1990 年的 250 万人呈指数级增长到 2016 年的 610 万人（PD Collaborators. Lancet Neurol. 2018; 17(11):939-53）。这是由于人口老龄化、寿命延长、疾病持续时间延长以及诊断技术的改进。我们研究的目的是确定过去十年中与帕金森病和帕金森病相关的死亡趋势。方法 我们使用代码 G20 (PD)、G21（继发性帕金森症）和 G22（分类为其他帕金森症）从国家统计办公室收集数据，提取 2013 年至 2021 年在这些情况下编码的死亡人数。仅适用于英格兰和威尔士。结果 2013 年至 2021 年所有代码的死亡总数分别为 4518、4950、5542、5734、5936、6508、6207、7414 和 7117。G.20 下编码的死亡人数远高于其他编码下的死亡人数。结论 与帕金森病相关的死亡人数逐渐增加，在过去 9 年中几乎翻了一番。尽管 Covid 19 可能是过去两年这一增长的原因之一，但总体呈上升趋势。我们认为这主要是由于帕金森病患者的寿命更长，导致患病率和持续时间增加。这与肌少症、虚弱、不动、认知障碍和吞咽困难有关，导致晚年死亡率增加。另一个原因可能是死亡证明中的记录更加准确。尽管有人担心死亡证明没有被准确编码以包括 PD（Hobson, Meara.2018；8(2):e018969），但引入法医服务后可能会有所改善。重要的是要认识到帕金森病日益增加的负担，使我们能够规划和投资资源来改善这些患者的护理。