Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature.

中文翻译：

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深入了解：aPKC 膜动力学的进展

非典型蛋白激酶 Cs (aPKC) 是蛋白激酶 PKC 家族的一部分，并且是非典型的，因为它们不对典型 PKC 激活剂二酰甘油 (DAG) 和 Ca2+ 做出反应。它们是极化细胞组织的核心，并且在多种癌症中不受控制。 aPKC 招募到质膜室对于它们遇到与极化功能相关的底物至关重要。然而，与其他 PKC 相比，非典型 PKC 在那里招募的机制直到最近仍然难以捉摸。在这里，我们将 aPKC 纳入其中，总结了最近关于将 aPKC 直接招募到膜上的报告，提供了对看似不一致的发现的见解，并将其与现有文献相结合。