Lysine methylation signaling is well studied for its key roles in the regulation of transcription states through modifications on histone proteins. While histone lysine methylation has been extensively studied, recent discoveries of lysine methylation on thousands of non-histone proteins has broadened our appreciation for this small chemical modification in the regulation of protein function. In this review, we highlight the significance of histone and non-histone lysine methylation signaling in skeletal muscle biology, spanning development, maintenance, regeneration, and disease progression. Furthermore, we discuss potential future implications for its roles in skeletal muscle biology as well as clinical applications for the treatment of skeletal muscle-related diseases.

中文翻译：

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骨骼肌生物学中的赖氨酸甲基化信号传导：从肌发生到临床见解

赖氨酸甲基化信号传导因其通过组蛋白修饰在转录状态调节中的关键作用而得到了深入研究。虽然组蛋白赖氨酸甲基化已被广泛研究，但最近在数千种非组蛋白上发现赖氨酸甲基化拓宽了我们对蛋白质功能调节中这种微小化学修饰的认识。在这篇综述中，我们强调了组蛋白和非组蛋白赖氨酸甲基化信号在骨骼肌生物学、发育、维持、再生和疾病进展中的重要性。此外，我们还讨论了其在骨骼肌生物学中的作用以及治疗骨骼肌相关疾病的临床应用的潜在未来影响。