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Fecal Microbiota Transplantation: Information for the Pediatrician.
Pediatrics ( IF 8 ) Pub Date : 2023-12-01 , DOI: 10.1542/peds.2023-062922
Maria Oliva-Hemker 1 , Stacy A Kahn 2 , William J Steinbach 3 , ,
Affiliation  

Fecal microbiota transplantation (FMT) involves the delivery of an entire microbial community from a healthy donor to a recipient with the intention of ameliorating or curing a specific disease. Current evidence strongly supports a role for FMT in the treatment of Clostridiodes difficile infection, with cure rates of approximately 80% to 90%. This success has led to increasing attention for FMT as a potential therapeutic intervention for other conditions associated with disturbances of the intestinal microbiome, including inflammatory bowel diseases, autism spectrum disorder, and obesity. This clinical report endorses the joint society statement by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition and is meant to provide the general pediatrician with a broad overview to enable appropriate guidance to families seeking FMT as treatment of a child's condition.

中文翻译:

粪便微生物群移植:给儿科医生的信息。

粪便微生物群移植 (FMT) 涉及将整个微生物群落从健康供体移植到受体,目的是改善或治愈特定疾病。目前的证据强烈支持 FMT 在治疗艰难梭菌感染中的作用,治愈率约为 80% 至 90%。这一成功引起了人们越来越多的关注 FMT 作为一种潜在的治疗干预措施,用于治疗与肠道微生物组紊乱相关的其他疾病,包括炎症性肠病、自闭症谱系障碍和肥胖。本临床报告赞同北美儿科胃肠病学、肝病学和营养学会以及欧洲儿科胃肠病学、肝病学和营养学会的联合声明,旨在为普通儿科医生提供广泛的概述,以便为家庭提供适当的指导寻求 FMT 作为儿童病情的治疗方法。
更新日期:2023-12-01
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