INTRODUCTION Early-onset small bowel adenocarcinoma (EO-SBA) is a rare and poorly characterized entity. METHODS This retrospective study conducted on an international multicenter cohort of 208 SBA patients aimed at comparing clinico-pathologic features of EO-SBAs (age <50 years at SBA diagnosis) and late-onset SBAs (age ≥50 years at SBA diagnosis). RESULTS The presence of predisposing pathologic conditions was significantly more common in the EO-SBA group compared to the late-onset SBAs (p=0.003, Fisher exact test; relative risk: 1.50, 95% confidence interval: 1.20-1.86). This difference is mainly due to the significantly higher prevalence of celiac disease among EO-SBA patients. DISCUSSION EO-SBA is strongly associated with predisposing conditions, particularly with celiac disease, highlighting the importance of routine screening for celiac disease in EO-SBA patients.

中文翻译：

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早发性和晚发性小肠腺癌的临床病理比较：一项多中心国际研究。

简介 早发性小肠腺癌（EO-SBA）是一种罕见且特征不明的实体。方法 这项回顾性研究对 208 名 SBA 患者组成的国际多中心队列进行，旨在比较 EO-SBA（SBA 诊断时年龄 <50 岁）和晚发 SBA（SBA 诊断时年龄≥50 岁）的临床病理特征。结果 与晚发 SBA 组相比，EO-SBA 组中易诱发病理状况的存在明显更常见（p=0.003，Fisher 精确检验；相对风险：1.50，95% 置信区间：1.20-1.86）。这种差异主要是由于 EO-SBA 患者乳糜泻的患病率显着较高。讨论 EO-SBA 与诱发因素密切相关，尤其是乳糜泻，这凸显了对 EO-SBA 患者进行乳糜泻常规筛查的重要性。