BACKGROUND AND OBJECTIVES The coronavirus disease 2019 (COVID-19) pandemic may have impacted parental attitudes toward childhood vaccines. However, few data sources followed attitudes before and after onset of the pandemic. We used data from a parental survey to describe the effect of the pandemic on parental attitudes toward childhood vaccines. METHODS Data were analyzed from the Health eMoms survey which randomly sampled birthing parents in Colorado from 2018 to 2021 on several health topics including vaccine hesitancy. Population weighted multivariable regression was used to measure the association between overall vaccine hesitancy and 5 individual hesitancy questions and different COVID-19 pandemic periods: prepandemic (April 2018-February 2020); pandemic prevaccine (April 2020-December 2020); and pandemic postvaccine (January 2021-August 2021), adjusting for demographic factors. RESULTS Overall, 20.4% (726/3553) of respondents were vaccine hesitant. Vaccine hesitancy during pandemic time periods was not different from the prepandemic period (prevaccine adjusted odds ratio [aOR] = 0.82, 95% confidence interval [CI] = 0.65-1.04; postvaccine aOR = 1.07, 95% CI = 0.85-1.34). In analyses of individual hesitancy questions, parents were more likely to be unsure about trusting vaccine information in the pandemic postvaccine time period compared with the prepandemic period (aOR = 2.14; 95% CI = 1.55-2.96), and less likely to be unsure about their hesitancy toward childhood vaccines (aOR = 0.48; 95% CI = 0.27-0.84). CONCLUSIONS The COVID-19 pandemic was not associated with changes in parental vaccine hesitancy overall, although there were changes in trust about vaccine information and a polarization of vaccination attitudes.

中文翻译：

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COVID-19 流行病和家长对常规儿童疫苗的态度。

背景和目标 2019 年冠状病毒病 (COVID-19) 大流行可能影响了父母对儿童疫苗的态度。然而，很少有数据来源追踪大流行爆发前后的态度。我们使用父母调查的数据来描述大流行对父母对儿童疫苗态度的影响。方法 对 Health eMoms 调查的数据进行了分析，该调查在 2018 年至 2021 年期间对科罗拉多州的生育父母进行了随机抽样，调查了包括疫苗犹豫在内的多个健康主题。使用人群加权多变量回归来衡量整体疫苗犹豫与 5 个个体犹豫问题和不同的 COVID-19 大流行时期之间的关联：大流行前（2018 年 4 月至 2020 年 2 月）；大流行预疫苗接种（2020年4月至2020年12月）；以及大流行疫苗接种后（2021 年 1 月至 2021 年 8 月），根据人口因素进行调整。结果 总体而言，20.4% (726/3553) 的受访者对疫苗犹豫不决。大流行期间对疫苗的犹豫与大流行前没有什么不同（疫苗接种前调整优势比[aOR] = 0.82，95%置信区间[CI] = 0.65-1.04；疫苗接种后aOR = 1.07，95% CI = 0.85-1.34）。在对个人犹豫问题的分析中，与大流行前时期相比，父母在大流行疫苗接种后时期更有可能不确定是否信任疫苗信息（aOR = 2.14；95% CI = 1.55-2.96），并且不太可能不确定他们对儿童疫苗接种犹豫不决（aOR = 0.48；95% CI = 0.27-0.84）。结论 尽管人们对疫苗信息的信任发生了变化，并且疫苗接种态度出现了两极分化，但 COVID-19 大流行与父母对疫苗犹豫的总体变化无关。