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Osteoporosis and Fragility Fractures in Patients With Cirrhosis Evaluated for Liver Transplantation: Identification of High-Risk Patients Based on Computed Tomography at Evaluation.
The American Journal of Gastroenterology ( IF 9.8 ) Pub Date : 2023-11-10 , DOI: 10.14309/ajg.0000000000002507
Clément Nachef 1, 2 , Valérie Bousson 3 , Nadia Belmatoug 4 , Martine Cohen-Solal 1, 2 , Valérie Vilgrain 5 , Olivier Roux 6 , Claire Francoz 6 , François Durand 6 , Thomas Funck-Brentano 1, 2
Affiliation  

INTRODUCTION Osteoporosis in candidates for liver transplantation (LT) is often underdiagnosed despite the important consequences of morbidity. METHODS We included 376 patients with cirrhosis evaluated for LT with available computed tomography (CT) scans. Prevalent vertebral fractures (VFs) were identified on CT reconstructions, and bone density was assessed by measuring CT attenuation of the L1 vertebra (L1-CT). RESULTS We identified 139 VFs in 55 patients (14.6%). Logistic regression models showed that low L1-CT was the only independent determinant of VF. DISCUSSION In patients with cirrhosis evaluated for LT, CT scans identified persons with severe osteoporosis without additional costs.

中文翻译:

接受肝移植评估的肝硬化患者的骨质疏松症和脆性骨折:基于评估时的计算机断层扫描识别高危患者。

简介 尽管发病率有重要后果,但肝移植 (LT) 候选者的骨质疏松症经常被诊断不足。方法 我们纳入了 376 名肝硬化患者,并通过可用的计算机断层扫描 (CT) 扫描进行了 LT 评估。通过 CT 重建识别出常见的椎体骨折 (VF),并通过测量 L1 椎骨 (L1-CT) 的 CT 衰减来评估骨密度。结果 我们在 55 名患者 (14.6%) 中发现了 139 个室颤。Logistic 回归模型显示,低 L1-CT 是 VF 的唯一独立决定因素。讨论 在接受 LT 评估的肝硬化患者中,CT 扫描可识别患有严重骨质疏松症的患者,而无需额外费用。
更新日期:2023-11-10
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