Graphene oxide (GO) enwrapped SiO₂/TiO₂ hollow nanoparticles (GO‐HNP) are synthesized by the Stöber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibility and high uniformity in diameter (ca. 50 nm). Furthermore, this nanoparticle shows λ=808 nm laser induced PpIX release properties (photoinduced “on–off” drug‐release system). GO‐HNP‐PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of PTT and PDT exhibits powerful anticancer properties. When cancer cells are treated with GO‐HNP‐PpIX and irradiated with both visible light and a NIR laser, the cell viability drops dramatically to 2.5 %, which is an anticancer effect approximately 13 times higher than that obtained in a previous study. Moreover, no significant cell damage has been observed under λ=808 nm laser irradiation. The GO‐HNP‐PpIX system suggests an external stimuli‐responsive efficient anticancer treatment effect toward human breast cancer cells.

中文翻译：

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载有光敏剂的氧化石墨烯包裹的SiO2 / TiO2空心纳米粒子用于光热和光动力联合治疗

氧化石墨烯（GO）包裹的SiO ₂ / TiO ₂中空纳米颗粒（GO-HNP）是通过Stöber方法合成的，并用作负载原卟啉IX（PpIX）的纳米载体。合成的纳米颗粒具有高分散性和直径（约50nm）的高均匀性。此外，该纳米粒子显示出λ= 808 nm激光诱导的PpIX释放特性（光诱导的“开-关”药物释放系统）。GO‐HNP‐PpIX用于诱导光热疗法（PTT）和光动力疗法（PDT）。PTT和PDT的协同作用显示出强大的抗癌特性。当用GO‐HNP‐PpIX处理癌细胞并用可见光和NIR激光照射时，细胞活力急剧下降至2.5％，这是一种抗癌作用，比以前的研究高约13倍。而且，在λ＝ 808nm的激光照射下未观察到明显的细胞损伤。GO‐HNP‐PpIX系统建议对人乳腺癌细胞具有外部刺激反应有效的抗癌治疗作用。